Actively Recruiting

Age: 0Years - 18Years
All Genders
ID04331522

Allergen Provocations at Hans Christian Andersen Children's Hospital

Led by Josefine Gradman · Updated on 2025-07-10

8000

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to understand how co-existing health conditions, medical history, and allergy tests affect the results of allergen provocation tests in children. The study includes children from birth up to 18 years old who are being investigated for allergies to foods or antibiotics. It is a prospective observational study conducted at the Hans Christian Andersen Children's Hospital. Participants undergo oral provocation tests where small, increasing amounts of allergens are given to assess allergic reactions. The allergens studied include antibiotics and a variety of common food allergens such as milk, egg, peanut, hazelnut, sesame, wheat, various nuts, soy, fish, shellfish, and poppy seed. Each child is assigned to a group based on the specific allergen they are being tested for. During the study, data on demographics, co-existing conditions, symptoms, skin prick tests, specific IgE levels, and details from the provocation tests are collected and entered into a database. Researchers will assess the relationship between allergy test results and provocation outcomes over a five-year period. Children will be monitored through these evaluations to better understand allergy responses and test effectiveness.

CONDITIONS

Brief Title

Allergen Provocations- HCA Children's Hospital

Who Can Participate

Age: 0Years - 18Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical suspicion of allergy to foods or antibiotics
  • Informed consent obtained
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - Single visit

Participants undergo oral provocation tests to assess allergy to specific foods or antibiotics.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 5 years

Participants are observed for up to 5 years to assess the association of allergy tests with allergen provocation results.

Trial Site Locations

Total: 1 location

1

Hans Christian Andersen Children's Hospital

Odense, Odense C, Denmark, 5000

Actively Recruiting

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Research Team

J

Josefine Gradman, phd

S

Susanne Halken, DMSc

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

15

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