Oral food challenge with raw egg: Sixty-minute- compared with 30-minute dosing interval.
Josefine Gradman, Birgitte Tusgaard Petersen, Susanne Halken
https://pubmed.ncbi.nlm.nih.gov/35719001Actively Recruiting
Led by Josefine Gradman · Updated on 2025-07-10
8000
Participants Needed
1
Research Sites
52 weeks
Total Duration
This research aims to understand how co-existing health conditions, medical history, and allergy tests affect the results of allergen provocation tests in children. The study includes children from birth up to 18 years old who are being investigated for allergies to foods or antibiotics. It is a prospective observational study conducted at the Hans Christian Andersen Children's Hospital. Participants undergo oral provocation tests where small, increasing amounts of allergens are given to assess allergic reactions. The allergens studied include antibiotics and a variety of common food allergens such as milk, egg, peanut, hazelnut, sesame, wheat, various nuts, soy, fish, shellfish, and poppy seed. Each child is assigned to a group based on the specific allergen they are being tested for. During the study, data on demographics, co-existing conditions, symptoms, skin prick tests, specific IgE levels, and details from the provocation tests are collected and entered into a database. Researchers will assess the relationship between allergy test results and provocation outcomes over a five-year period. Children will be monitored through these evaluations to better understand allergy responses and test effectiveness.
CONDITIONS
Allergen Provocations- HCA Children's Hospital
You may qualify if you...
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single visit
Participants undergo oral provocation tests to assess allergy to specific foods or antibiotics.
1 visit (in-person)
Duration - Up to 5 years
Participants are observed for up to 5 years to assess the association of allergy tests with allergen provocation results.
Total: 1 location
1
Hans Christian Andersen Children's Hospital
Odense, Odense C, Denmark, 5000
Actively Recruiting
J
Josefine Gradman, phd
S
Susanne Halken, DMSc
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
15
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Josefine Gradman, Birgitte Tusgaard Petersen, Susanne Halken
https://pubmed.ncbi.nlm.nih.gov/35719001Birgitte Tusgaard Petersen, Josefine Gradman
https://pubmed.ncbi.nlm.nih.gov/32818157