Actively Recruiting
Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.
Led by Gene Solutions · Updated on 2026-01-16
50
Participants Needed
2
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational clinical trial, aiming to investigate whether the ctDNA dynamics could predict early response to ICIs in patients with advanced-stage cancer. Moreover, conventional tumor markers PD-L1, TMB and MSI are to be investigated for their combined prognostic values in ICI treatment.
CONDITIONS
Official Title
Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years and older, both genders.
- Diagnosed with stage IV cancer (lung, colorectal, breast, liver, gastric, etc.) and indicated for immune checkpoint inhibitor (ICI) treatment, either first or second line.
- Concurrent chemotherapy with ICI is allowed.
- Formalin-fixed paraffin-embedded (FFPE) or fine needle aspiration (FNA) tumor sample is available.
- Compliant with the treatment protocol.
- Provided consent to participate in the study.
You will not qualify if you...
- Already started immune checkpoint inhibitor (ICI) treatment before enrollment.
- Receiving consolidation ICI therapy (e.g., Durvalumab).
- Already started chemotherapy before enrollment.
- Medical or psychiatric conditions or occupational responsibilities that may prevent compliance with the protocol.
- Did not agree to participate in the study.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of Medicine and Pharmacy at HCMC
Ho Chi Minh City, Hồ Chí Minh, Vietnam
Actively Recruiting
2
Medical Genetics Institute
Ho Chi Minh City, Vietnam
Not Yet Recruiting
Research Team
L
Lan NL Tu, PHD
CONTACT
V
VAN T Phan, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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