Actively Recruiting

Age: 18Years - 80Years
All Genders
ID06486649

Application of a Multimodal Large Language Model to Assist Diagnosis for Heart Failure With Preserved Ejection Fraction

Led by Peking University Third Hospital · Updated on 2024-07-03

80

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

P

Peking University Third Hospital

Lead Sponsor

T

Tianjin Medical University General Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

Heart failure with preserved ejection fraction (HFpEF) is a challenging heart condition that remains difficult to diagnose accurately, leading to delays in treatment. Researchers are evaluating a multimodal large language model designed to screen for HFpEF by analyzing diverse medical data such as patient records, images, and audio symptoms. This study compares the model's effectiveness with the traditional clinical assessment process used by cardiologists. The study involves two diagnostic approaches: the standard routine consultation following expert consensus guidelines and the multimodal large language model system called MedGuide-72B. During patient visits, the model collects and analyzes data from the routine clinical interaction to make its diagnosis. Both methods aim to identify HFpEF in patients suspected of having this condition, focusing on integrating and interpreting complex, multi-source medical information. Participants are cardiology inpatients aged 18 to 80 years suspected of HFpEF based on heart ultrasound and symptoms like breathlessness or swelling. Researchers will measure diagnostic accuracy, sensitivity, specificity, patient satisfaction, diagnosis time, economic costs, physician workload, and diagnosis efficiency over about eight months. The study collects data during routine care visits without altering treatment, and participants will be monitored for the quality and consistency of the diagnostic processes.

CONDITIONS

Brief Title

Application of Multimodal Large Language Model in HFpEF

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 80 years, male or female
  • Cardiology inpatients suspected of heart failure with preserved ejection fraction, with heart ultrasound showing LVEF ≥50% and either left ventricular hypertrophy or left atrial enlargement, or abnormal diastolic cardiac function
  • Current or previous symptoms of heart failure including breathlessness, tiredness, nausea, or swelling in both legs
  • Voluntary participation with signed informed consent
Not Eligible

You will not qualify if you...

  • Acute heart failure or sudden worsening of chronic heart failure
  • Severe coronary artery narrowing (≥75% stenosis) without treatment
  • Unable to perform or contraindicated for exercise stress echocardiography
  • Participation in other clinical trials
  • Severe liver, kidney, or blood system diseases or other chronic illnesses
  • Unable to follow trial procedures
  • Refusal to sign informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Approximately 8 months

Participants undergo routine diagnostic and therapeutic procedures as well as diagnosis using the multimodal large language model to assess heart failure with preserved ejection fraction (HFpEF).

During routine consultation visits

Long-term Monitoring

Duration - Up to study completion (around 8 months)

Participants are observed throughout the study period to evaluate diagnostic specificity, sensitivity, consistency, and other outcomes related to HFpEF diagnosis.

Ongoing data collection during study period

Trial Site Locations

Total: 1 location

1

Peking UniversityThird Hospital

Beijing, Beijing Municipality, China

Actively Recruiting

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Research Team

X

Xiangbin Meng

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.

Michelle M Kittleson, Gurusher S Panjrath, Kaushik Amancherla...

https://pubmed.ncbi.nlm.nih.gov/37137593