Study of Arterial Stiffening to Predict Diastolic Heart Dysfunction and Heart Failure with Preserved Ejection Fraction in Adults

What this Trial Is About

Researchers are investigating patients at risk for heart failure with preserved ejection fraction HFpEF to understand how stiffening of the arteries may be linked to the development of heart problems affecting the hearts ability to relax and fill properly. This observational study aims to explore the connection between arterial stiffness and cardiac diastolic dysfunction over time. The research is sponsored by University Medical Center Goettingen and focuses on cardiovascular health in adults, especially those with risk factors like high blood pressure or diabetes. Participants will undergo structured clinical assessments including transthoracic echocardiography and pulse-wave analysis to measure arterial stiffness and heart function. The study will track changes in heart function scores, the onset of HFpEF, and cardiovascular events over a 24-month period. No investigational treatments or medications are administered, as this is an observational study focused on monitoring and data collection. Throughout the study, participants will have evaluations of heart function and related health measures at regular intervals up to 24 months. These include assessments of heart failure scores, blood markers like NT-proBNP, kidney function, and symptoms of heart failure. Researchers will monitor changes in these measures to understand disease progression and cardiovascular health. The study allows adults 18 years and older with certain risk factors to participate, and safety and health will be closely observed during the study period.

Arterial Stiffening as a Predictor for Diastolic Cardiac Dysfunction and HFpEF