Actively Recruiting
Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application
Led by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Updated on 2025-05-16
70
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating the use of arterial spin labeling (ASL), a non-invasive MRI technique, to measure blood flow in the retinal tissue and the human eye. This study focuses on testing the precision and specificity of the MRI protocol for accurately measuring regional blood flow (rBF) and cerebral blood flow (cBF) without the need for contrast injections. The study includes both healthy volunteers and patients with retinal diseases such as thyroid associated orbitopathy (TAO), inflammatory optic neuropathy (ION), and ischemic optic neuropathy. Participants will undergo an MRI scan using the ASL technique as described in the study protocol. The study groups include healthy volunteers with normal vision, chronic patients with decreased visual acuity from the specified diseases, and patients in the acute phase of these diseases who will be examined again in the chronic phase. The study is non-randomized and does not involve masking or placebo controls. During the study, participants will have MRI assessments to measure blood perfusion in the retina at various time points, including repeatability measurements in volunteers over 2 months and perfusion measurements in patients during acute and chronic phases over 4 years. Researchers will monitor the safety and tolerability of the MRI procedure and observe changes in retinal blood flow. Participation involves following the study protocol and signing informed consent, with ongoing evaluation of retinal perfusion as the primary outcome.
CONDITIONS
Brief Title
Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Carrier of target pathologies: thyroid associated orbitopathy optic neuropathy, inflammatory optic neuropathy, ischemic optic neuropathy
- No cardiovascular risk factors or other ophthalmological pathology
- Agree to follow the study protocol after reading the patient information document
- Sign the informed consent form to participate
- Have no contraindications to an MRI examination
You will not qualify if you...
- Usual contraindications to MRI such as pacemaker, metallic foreign body, or cochlear implant
- Severe claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Repeatability measurement over 2 months for healthy volunteers; up to 4 years for patients in acute and chronic phases
Participants undergo MRI perfusion imaging using a non-invasive ASL MRI technique to assess blood perfusion in the eye.
Multiple MRI visits over the study duration depending on participant group
Trial Site Locations
Total: 1 location
1
Cliniques Universitaires Saint Luc
Brussels, Brussels Capital, Belgium, 1200
Actively Recruiting
Research Team
I
Idil Günes-Tatar, MD
T
Thierry Duprez, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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