Actively Recruiting

Age: 18Years +
All Genders
ID07045532

Assessment the Effectiveness of Bronchoscopic Thermal Vapor Ablation in Chronic Obstructive Pulmonary Disease and Ablation in Pulmonary Nodules by Pulmonary Magnetic Resonance Imaging

Led by Shanghai Chest Hospital ยท Updated on 2025-07-01

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of bronchoscopic thermal vapor ablation (BTVA) in patients with chronic obstructive pulmonary disease (COPD) and the ablation of pulmonary nodules in lung cancer patients. This observational study uses innovative magnetic resonance imaging (MRI) techniques to assess lung function and treatment effects after surgery. The study focuses on the use of PREFUL_MRI to evaluate lung ventilation and perfusion in COPD patients after lung volume reduction surgery and GRASP_MRI to analyze hemodynamic parameters following pulmonary nodule ablation. Participants include COPD patients treated with thermal steam ablation and patients with malignant pulmonary nodules who have undergone ablative treatments such as radiofrequency, microwave, or freezing ablation. The study observes these patients from enrollment through follow-up periods lasting up to six months post-surgery for COPD and up to three months post-surgery for pulmonary nodules. MRI scans using the PREFUL and GRASP sequences are performed to monitor lung function and treatment impact. During the study, participants will undergo MRI assessments to measure ventilation, perfusion, and hemodynamic changes in the lungs after their respective treatments. Researchers will closely monitor these lung imaging parameters to evaluate treatment efficacy. The study participation spans from enrollment up to six months for COPD patients and three months for pulmonary nodule patients, with a focus on tracking lung function and safety post-treatment using advanced MRI techniques.

CONDITIONS

Brief Title

Assessment the Effectiveness of BTVA in COPD and Ablation in Pulmonary Nodules by Pulmonary MRI

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age over 18 years old
  • Patients with pulmonary nodules indicated by chest CT, pathologically diagnosed as malignant, and receiving ablative treatment such as radiofrequency, microwave, or freezing
  • Patients diagnosed with COPD according to the GOLD principle and treated with thermal steam ablation
  • Ability to understand the study and sign informed consent
Not Eligible

You will not qualify if you...

  • Presence of pure ground glass nodules on chest CT in pulmonary nodule patients
  • Patients with metal implants like pacemakers, heart stents, artificial heart valves, or those with claustrophobia or allergy to contrast media unsuitable for MRI
  • Severe cardiopulmonary dysfunction or other diseases increasing the risk of ablation surgery
  • Severe COPD exacerbation or pneumonia within the past four weeks

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - From enrollment to up to 6 months post-surgery for COPD patients, and up to 3 months post-surgery for pulmonary nodule patients

Participants undergo diagnostic procedures including pulmonary magnetic resonance imaging (MRI) to assess lung function and pulmonary nodules.

Multiple MRI assessments during this period

Long-term Monitoring

Duration - Up to 6 months post-surgery for COPD and up to 3 months post-surgery for pulmonary nodule patients

Participants are monitored following ablative treatment or lung volume reduction surgery to evaluate lung function and treatment effects over time.

Follow-up visits may occur throughout the post-treatment period

Trial Site Locations

Total: 1 location

1

Shanghai chest hospital

Shanghai, Shanghai Municipality, China, 200030

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Research Team

L

Lin Ye, MD

J

Jiayuan Sun, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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