Comparison of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With a History of Mitral Valve Intervention for Mitral Stenosis With Healthy Subjects

What this Trial Is About

Heart valve diseases are a leading cause of illness and death after coronary artery disease, hypertension, and heart failure. Mitral stenosis narrows the heart's mitral valve, limiting blood flow and causing symptoms like shortness of breath, fatigue, and difficulty with physical activity. This condition also reduces exercise capacity, worsens quality of life, and impairs respiratory function. Research groups studying these effects often lack uniformity, and most focus on patients who have undergone a specific procedure called percutaneous mitral balloon valvuloplasty. The study compares patients who have had surgery for mitral stenosis to healthy individuals. It evaluates exercise capacity using a cardiopulmonary exercise test, muscle oxygenation with near-infrared spectroscopy, respiratory functions with spirometry, respiratory muscle strength and endurance with specialized devices, aortic stiffness with an arteriograph, physical activity with a multisensor monitor, and quality of life using the SF-36 questionnaire. Participants include a patient group and a healthy control group, with assessments done over about one year. Participants will undergo various tests to measure exercise capacity, muscle oxygenation, aortic stiffness, respiratory muscle strength and endurance, lung function, physical activity, and quality of life. These tests include exercise testing, respiratory measurements, and monitoring of daily activity levels. The study tracks these outcomes continuously through one year to understand differences between those who had mitral valve surgery and healthy people. This helps researchers learn how surgery affects heart and lung function as well as overall well-being.

Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral Stenosis