Actively Recruiting
Assessment of the Ocular Microbiome in Health and Disease
Led by Vanderbilt University Medical Center · Updated on 2026-01-22
500
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the community of microbial organisms living on the surface of the eye, known as the ocular microbiome, to understand its role in eye health and disease. This observational study aims to identify the normal bacteria present, factors that encourage their growth, and how these microbes may protect against or contribute to eye conditions. The study responds to the need for a comprehensive database describing the ocular microbiome in a healthy population. Participants will be grouped based on their eye health status, including those with normal eyes, mild glaucoma, non-infectious keratopathy, dry and wet age-related macular degeneration, and diabetic retinopathy. The study involves collecting samples through simple swabs of both eyes to analyze microbial DNA and other components using advanced sequencing methods over a three-year period. During the study, participants will undergo regular collection of eye swab samples and associated clinical data such as demographic information, medications, and allergies. Researchers will track changes in the ocular microbiome and assess its composition and function using advanced genetic sequencing techniques. The primary outcome is to define the normal ocular microbiome, with secondary outcomes focusing on sequencing methods. Participation includes follow-up visits over several years to monitor these factors.
CONDITIONS
Brief Title
Assessment of the Ocular Microbiome in Health and Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Provide informed consent
- Have normal eyes with no ocular disease (Cohort A)
- Have mild primary open angle glaucoma or ocular hypertension controlled with no more than one prostaglandin eye drop daily for the past 6 months (Cohort B)
- Have non-infectious keratopathy not using prescription medication (over-the-counter artificial tears allowed) (Cohort C)
- Have dry age-related macular degeneration (Cohort D)
- Have wet age-related macular degeneration (Cohort E)
- Have diabetic retinopathy at any stage (Cohort F)
You will not qualify if you...
- Prior ocular disease affecting the front or back segments of the eye
- Any medical conditions except well-controlled diabetes or hypertension
- Unable to follow study procedures as described
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants provide ocular surface samples using a simple swab under the eyelids of both eyes along with associated clinical data collection.
1 to 2 visits depending on cohort assignment
Duration - Up to 3 years
Participants are observed over time to understand the ocular microbiome and its association with eye health and disease.
Periodic assessments may occur depending on cohort assignment
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
H
Havin Abdulkadir
S
Saige Priddy
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here