Study of Brain Activity and Avoidance Learning in Women with Anorexia Nervosa or Bulimia Nervosa Compared to Healthy Women Aged 18 to 39

What this Trial Is About

Researchers are studying the brain areas involved in avoidance learning in adult women aged 18 to 39 with eating disorders, specifically anorexia nervosa and bulimia nervosa, compared to healthy women. They aim to understand behavioral differences in avoidance learning, brain activity changes measured by functional magnetic resonance imaging fMRI, and differences in brain connectivity related to these disorders. The study includes 78 women with eating disorders and 26 healthy controls. Participants are grouped based on diagnostic criteria for anorexia nervosa, bulimia nervosa, or no eating disorder. The study uses brain imaging techniques like fMRI, computer tasks to assess learning behaviors, and self-report questionnaires and interviews. Brain responses to avoidance learning and connectivity are measured during sessions lasting 10 to 25 minutes. During the study, participants complete behavioral tasks, undergo fMRI scans to monitor brain activity and connectivity, and provide information through questionnaires and interviews. Researchers will measure learning rates, brain responses, and functional connectivity related to avoidance learning. The study monitors participants health and eligibility carefully, including weight and medication use, over the study period which starts in August 2024 and continues through July 2027.

Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa