Actively Recruiting
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
Led by Mayo Clinic · Updated on 2025-10-08
1120
Participants Needed
5
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing the effectiveness and safety of two antibiotics, Azithromycin and Doxycycline, in adult patients hospitalized with community-acquired pneumonia (CAP) who are also treated with Beta-lactam antibiotics. This study focuses on adults admitted with CAP and aims to provide important information on which antibiotic may be more suitable when combined with standard Beta-lactam therapy. Participants will be randomly assigned to receive either Azithromycin or Doxycycline alongside Beta-lactam treatment. Both antibiotics may be given orally or intravenously within 12 hours of hospital admission, with treatment lasting between 5 to 7 days. The study includes two groups: one receiving Doxycycline and the other Azithromycin, both as part of standard care. During the study, researchers will track hospital-free days over 28 days as the main outcome. They will also monitor oxygen-free days, mortality up to 180 days, and the need for advanced respiratory support or in-hospital death within 28 days. Participants will be closely observed throughout their hospital stay and follow-up periods to assess these outcomes and ensure safety.
CONDITIONS
Brief Title
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients over 18 years old
- Hospitalized with community-acquired pneumonia
- Receiving beta-lactam antibiotic plus azithromycin or doxycycline within 12 hours of admission
- Receiving treatment started in the emergency department
- Able to receive study treatment within 12 hours of hospital admission
You will not qualify if you...
- High suspicion of Legionella pneumonia
- Allergy or contraindication to azithromycin or doxycycline
- Antibiotics prescribed for conditions other than community-acquired pneumonia
- Pregnant women
- Severe community-acquired pneumonia as defined by ATS/IDSA criteria
- Corrected QT prolongation (>440 ms in men, >460 ms in women)
- Receiving antibiotics other than azithromycin or doxycycline (e.g., quinolones)
- Hospital admission longer than 24 hours before enrollment
- Known prisoner status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 5 to 7 days
Participants receive either Doxycycline or Azithromycin in combination with beta-lactam therapy starting within 12 hours of hospital admission for community-acquired pneumonia.
1 to 2 visits during hospitalization
Trial Site Locations
Total: 5 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Not Yet Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
Not Yet Recruiting
3
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States, 56001
Not Yet Recruiting
4
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
5
Mayo Clinic Health System-La Crosse
La Crosse, Wisconsin, United States, 54601
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here