Real-World Study of Patients Aged 16 and Older with Myocardial Infarction and Non-Obstructive Coronary Arteries MINOCA Tracking Diagnosis and Outcomes at Barts Health NHS Trust

What this Trial Is About

Researchers are studying patients diagnosed with myocardial infarction with non-obstructive coronary arteries MINOCA, a condition affecting 1 to 13% of those with acute myocardial infarction. This condition presents challenges because coronary revascularization is not suitable, and current guidelines for management are lacking. The study aims to better understand the diagnosis, treatment, and long-term outcomes for these patients, whose prognosis is uncertain but guarded compared to those with obstructive coronary artery disease. This observational study uses a clinical database collecting information on all patients referred to the Interventional Cardiology team at Barts Health NHS Trust since April 2015. It includes patients aged 16 years and older with MINOCA or unclear causes of troponin rise. No additional procedures or investigations are performed solely for research. Both medically managed patients and those undergoing interventions are included, and data are anonymized before analysis. Participants clinical data are collected during routine care without extra visits or procedures. Researchers assess outcomes such as mortality at 30 days and 1 year, formal diagnosis timing and cause of troponin rise, and changes in symptoms two months after initial review. The study continues indefinitely, aiming to evaluate the safety, feasibility, and effectiveness of further investigations in patients with MINOCA in a real-world setting.

Barts-MINOCA Registry