Actively Recruiting
A Series of N-of-1 Randomised, Adaptive, Blinded, Placebo-Controlled Trials of Overnight In-Bedroom Air Filtration as Adjuvant Treatment in Reducing Inflammatory Biomarkers Among Survivors of Adult-Onset Cancer With Elevated C-Reactive Protein
Led by University College, London · Updated on 2026-03-27
10
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
I
IQAir AG
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether using a portable air filtration system overnight in bedrooms can reduce inflammation and heart-related biomarkers in adult cancer survivors at high risk for cardiovascular problems. The study focuses on individuals living in urban areas of Valencia, Spain, where air pollution levels exceed international safety limits. This trial uses a series of personalized randomized experiments (N-of-1 trials) to study the impact of filtered air on blood markers like C-reactive protein (CRP). Participants will undergo three treatment cycles during the blinded phase, each lasting 14 days with filtered air and 14 days with sham (unfiltered) air using the same device. The air filtration runs nightly for at least 7 hours between 10:00 p.m. and 10:00 a.m. If no meaningful reduction in CRP is observed after these cycles, participants enter an open-label phase with a 14-day no-treatment period followed by 14 days of continuous filtered air both day and night. The device uses HyperHEPA technology and dose adjustments are allowed for noise concerns. Throughout the study, participants will provide blood samples at baseline and on days 7 and 14 of each period to measure CRP and other biomarkers related to inflammation and cardiovascular health. Blood pressure readings will also be taken at these times. Air quality inside and outside the home will be continuously monitored. Participants will complete weekly questionnaires about exercise, diet, sleep quality, and daily activity patterns. The study lasts 4 to 12 weeks depending on response, with safety and adherence closely observed.
CONDITIONS
Brief Title
In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult-onset cancer survivors diagnosed with breast, colon, colorectal, rectum, prostate, non-small lung, Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphoid leukemia, or chronic myeloid leukemia.
- Aged 18 to 75 years at cancer diagnosis.
- People of all genders and racial/ethnic backgrounds.
- Non-smokers for at least the past 12 months.
- No evidence of metastatic disease.
- Evidence of complete remission after treatment.
- Completed definitive cancer treatment at least 12 months prior.
- Maintenance therapy allowed if stable and ongoing during trial.
- High inflammatory cardiac risk with CRP ≥3 to <10 mg/L or ≥10 mg/L if acute inflammation is ruled out.
- Stable hypertension if applicable: no medication changes in prior 30 days, systolic BP <160 mm Hg.
- Controlled and stable chronic medical conditions allowed.
- Routine prescribed medications continued during trial.
- Living in specified highly polluted urban areas of Valencia.
- Permanent residence in usual home for at least 3 months prior with no plans to move during trial.
- Living in a non-smoking household.
- Internet connection (Wi-Fi) at home.
- Signed informed consent prior to study procedures.
You will not qualify if you...
- Recently diagnosed with cancer or plans for cancer therapy or surgery during trial.
- Metastatic disease.
- Planned new medication prescription during trial.
- Uncontrolled hypertension: average systolic BP >160 mmHg over any 10-day period.
- History of uncontrolled or unstable chronic disease within 6 months.
- Psychiatric illness limiting compliance or informed consent.
- Chronic or recurrent infectious diseases or immunocompromised state.
- Alcohol or substance abuse in past 12 months.
- Shift workers with schedules outside 07:00 a.m. to 10:00 p.m.
- Plans to move from usual home during trial.
- Unwillingness to spend at least 7 hours overnight in bedroom.
- Pre-existing air filtration system improving household air quality.
- Unwilling to give consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 4 weeks
Participants are screened for eligibility to participate in the trial.
Up to 2 home visits for blood microsampling to measure CRP levels
Duration - Between 4 and 12 weeks depending on the number of treatment sets completed
Participants undergo a series of up to three 14-day treatment sets with either active or sham air filtration nightly in the bedroom during sleep hours, randomized and blinded. This crossover phase aims to reduce inflammatory biomarkers.
Participants use air purifiers nightly for at least 7 consecutive hours within a 10:00 p.m. to 10:00 a.m. window; biomarker measurements collected at baseline, day 7 and day 14 of each period
Duration - 14 days
A 2-week wash-out period follows the last blinded treatment set to allow any treatment effects to subside before further intervention.
No intervention during this period
Duration - 28 days
Participants who do not achieve clinically meaningful changes after the blinded phase receive 14 days without treatment followed by 14 days of continuous nightly and daily active air filtration in the bedroom at home.
Continuous operation of air purifier 24 hours/day in bedroom for 14 days; participants asked to remain in bedroom as much as possible and keep an activity log
Trial Site Locations
Total: 3 locations
1
Gil y Morte Primary Care Practice
Valencia, Spain
Actively Recruiting
2
Mallilla Primary Care Practice
Valencia, Spain
Actively Recruiting
3
Russafa Primary Care Practice
Valencia, Spain
Actively Recruiting
Research Team
E
Eva Hernandez-Garcia
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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