Actively Recruiting
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2026-05-12
816
Participants Needed
1
Research Sites
260 weeks
Total Duration
Researchers are conducting the Bern Intracoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry (BIOCORE) to study coronary artery disease (CAD). The registry focuses on patients undergoing both coronary computed tomography angiography (CCTA) and optical coherence tomography (OCT) to validate and develop advanced methods for assessing coronary plaque characteristics, lesion severity, and guidance for percutaneous coronary intervention (PCI). This research aims to better understand the relationship between plaque features and long-term clinical outcomes. Participants in this observational study will undergo paired CCTA and OCT imaging within 3 months. The study compares the diagnostic accuracy of new photon-counting CT technology and AI-guided CCTA analysis against the current gold standard, invasive OCT. Patients included have at least one vessel with 50% or greater stenosis on CCTA and OCT imaging is performed on native coronary arteries before any PCI. During the study, researchers will review imaging results to evaluate plaque phenotyping, lesion severity, and PCI planning accuracy. The main outcomes include comparing CCTA with OCT and assessing photon-counting versus conventional CCTA. Participants will be monitored based on their imaging data, with no additional interventions. The study helps advance non-invasive diagnostic methods and may influence future CAD treatment planning.
CONDITIONS
Bern Intracoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 months
Participants undergo coronary computed tomography angiography (CCTA) and invasive coronary angiography with optical coherence tomography (OCT) to assess coronary plaque morphology and lesion severity.
1 to 2 visits depending on imaging procedures
Duration - Up to several years until study completion
Participants are observed for long-term clinical outcomes related to coronary artery disease after imaging procedures.
Visits as per routine clinical follow-up
Total: 1 location
1
Department of Cardiology, Bern University Hospital Inselspital
Bern, Switzerland, 3010
Actively Recruiting
S
Sarah Bär, MD, PhD
R
Räber Lorenz, Prof. MD PhD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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