Bern Registry Comparing Intracoronary Optical Coherence Tomography and Coronary CT Angiography for Coronary Artery Disease

What this Trial Is About

Researchers are conducting the Bern Intracoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry BIOCORE to study coronary artery disease CAD. The registry focuses on patients undergoing both coronary computed tomography angiography CCTA and optical coherence tomography OCT to validate and develop advanced methods for assessing coronary plaque characteristics, lesion severity, and guidance for percutaneous coronary intervention PCI. This research aims to better understand the relationship between plaque features and long-term clinical outcomes. Participants in this observational study will undergo paired CCTA and OCT imaging within 3 months. The study compares the diagnostic accuracy of new photon-counting CT technology and AI-guided CCTA analysis against the current gold standard, invasive OCT. Patients included have at least one vessel with 50% or greater stenosis on CCTA and OCT imaging is performed on native coronary arteries before any PCI. During the study, researchers will review imaging results to evaluate plaque phenotyping, lesion severity, and PCI planning accuracy. The main outcomes include comparing CCTA with OCT and assessing photon-counting versus conventional CCTA. Participants will be monitored based on their imaging data, with no additional interventions. The study helps advance non-invasive diagnostic methods and may influence future CAD treatment planning.

Bern Intracoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry