Registry Study of Adults With Bicuspid Aortic Valve Disease Including Those With Family History or Idiopathic Ascending Aortic Aneurysm

What this Trial Is About

Researchers are gathering information on patients with bicuspid aortic valve disease to better understand this condition. This observational registry aims to assess the patterns of aortic dilation, how patients respond to medical therapy through serial imaging, and to explore potential genetic markers linked to the disease. The study is led by the University of Michigan and focuses on adults diagnosed with bicuspid aortic valve disease or related conditions. Participants include adults aged 18 and older who have been diagnosed with bicuspid aortic valve disease, have a family history of the disease, or have an idiopathic ascending aortic aneurysm. The registry collects data over a long period, including serial imaging and medical therapy responses, but there are no experimental treatments or interventions. The study follows participants for up to 30 years to characterize the disease progression. During the study, participants will provide informed consent and share medical information, including imaging results and genetic data if available. Researchers will monitor changes in the aorta and responses to treatments over time. The primary outcome is to better characterize patients with bicuspid aortic valve disease over 30 years. Participants usual medical care continues as normal during the study, and there are no restrictions on healthy volunteers.

Bicuspid Aortic Valve (BAV) Registry