Actively Recruiting
Led by China National Center for Cardiovascular Diseases · Updated on 2025-02-10
480
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to evaluate how the ascending aortic diameter changes in patients who undergo transcatheter aortic valve replacement (TAVR) for aortic stenosis. It particularly focuses on whether the diameter increases or remains stable after the procedure, especially in those with preoperative aortic dilatation. The study also seeks to identify factors that influence postoperative aortic dilatation in these patients. All participants undergo transfemoral TAVR, a procedure where the aortic valve is replaced through an artery in the leg. This observational study includes patients with severe aortic stenosis who are at high risk for traditional surgical valve replacement and who are suitable for this vascular access. The study does not involve additional treatments but monitors patients over time after their TAVR procedure. Participants will be followed to assess changes in the ascending aortic diameter at one and two years after TAVR. Researchers will also track rates of mortality and adverse aortic events during this period. Data collection includes clinical evaluations and imaging to measure aortic changes and monitor patient health outcomes throughout the study duration, which is planned to continue until March 2025.
CONDITIONS
Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo transfemoral transcatheter aortic valve replacement for aortic stenosis.
1 visit (in-person)
Duration - 2 years
Participants are monitored to evaluate changes in ascending aortic diameter and assess outcomes post-procedure.
Visits at 1-year and 2-year follow-up
Total: 1 location
1
National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
X
Xiangbin Pan, Dr
K
Kang An, Dr
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Kang An, Fengwen Zhang, Wenbin Ouyang...
https://pubmed.ncbi.nlm.nih.gov/39702010