Biocollection Study of Adults With ANCA-Associated Vasculitis Followed at the CERAINO Autoimmune Disease Reference Center Part of the Global BRAISE Rare Autoimmune Diseases Project

What this Trial Is About

This research focuses on ANCA-associated vasculitis, a group of rare and serious autoimmune diseases including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. These diseases can be fatal if untreated but are now managed as chronic conditions with corticosteroids and immunosuppressants. The study aims to better understand disease characteristics and identify predictors of relapse, mortality, and complications through long-term follow-up. Participants diagnosed with ANCA-associated vasculitis will be part of a single patient cohort undergoing collection of various biological samples and questionnaires. Blood and urinary samples will be collected at inclusion, annually for five years, and during relapses or treatment changes. Fecal samples and questionnaires will be collected at inclusion and repeated yearly or with disease events. This biocollection supports detailed study of disease progression and risk factors. Throughout the study, participants will have regular sample collections and complete questionnaires to monitor disease activity and outcomes. Researchers will assess relapse-free survival over five years along with mortality, disease activity scores, damage indices, refractory disease status, disability, and glucocorticoid toxicity. The study involves a long-term observation period up to ten years from 2022 to 2032 to gather comprehensive data for improved patient management.

Biocollection of Patients With ANCA Associated Vasculitis