Actively Recruiting
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Led by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Updated on 2026-03-20
4000
Participants Needed
1
Research Sites
1839 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Vasculitis is a group of diseases that inflame and damage blood vessels and tissue. It can cause many medical problems. Few tests can diagnose the disease, and none can reliably predict a relapse. Researchers want to study people s genes and follow people over time to see how the disease affects them. Objective: \- To learn the signs, symptoms, imaging tests, genetic markers, and blood tests that can help identify people with vasculitis and predict what will happen to them over time. Eligibility: * People age 3 and older who have or are thought to have vasculitis, or are related to someone with it. * Healthy volunteers. Design: * Participants will be evaluated by a doctor who has expertise caring for patients with vasculitis. * Participants will give a blood sample. Some will give a urine sample. * Some participants may have brushings or biopsies taken from the inside lining of the nose. * Images of participants blood vessels may be taken using scans. For some scans, participants will lie on a table that moves in and out of a cylinder that takes pictures. For some scans, a contrast agent may be injected into an arm vein. Other scans may use a radioactive form of sugar. Healthy minors will not have scans. * Some participants will answer questionnaires. - Some participants will have their tests done at NIH. Others will have their doctor take the blood, saliva, or cheek swab samples and send them to NIH. * Some participants will have one visit lasting 1-2 (but sometimes up to 4) days. Some participants may have follow-up visits every 3 - 6 months, indefinitely.
CONDITIONS
Official Title
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 3 years or older with vasculitis or suspected vasculitis
- Participants related to someone with vasculitis
- Healthy volunteers able to provide consent or assent
- Subjects fulfilling classification criteria for GPA, PAN, EGPA, GCA, TAK, or MPA
- Subjects with other suspected systemic or single-organ vasculitides
You will not qualify if you...
- Participants younger than 3 years old
- Participants with active malignancy or infection
- Participants unable to provide consent or assent
- Participants with bleeding disorders or on certain anticoagulant medications (coumadin, heparin, clopidogrel) excluded from nasal brushing or biopsy studies
- Healthy volunteers diagnosed with vasculitis or autoimmune/autoinflammatory diseases
- Pregnant or breastfeeding participants
- Healthy volunteers with bleeding disorders or on certain anticoagulants excluded from nasal brushing studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Shanni Liu
CONTACT
P
Peter C Grayson, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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