A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.
Carmelo Carmona-Rivera, Monica M Purmalek, Erica Moore...
https://pubmed.ncbi.nlm.nih.gov/28194438Actively Recruiting
Age: 3Years +
All Genders
Healthy Volunteers
ID02257866
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Led by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Updated on 2026-06-05
4000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying idiopathic systemic vasculitis, a group of rare diseases that cause inflammation and damage to blood vessels and tissues. These diseases can be life-threatening and have a chronic course with unpredictable relapses. The study aims to understand the signs, symptoms, imaging findings, genetic markers, and blood tests that can help identify vasculitis and predict its progression over time in both children and adults. Participants include those with diagnosed or suspected vasculitis and healthy volunteers. Evaluations involve detailed medical history, physical exams, blood and sometimes urine samples, and in some cases nasal biopsies. Imaging tests of blood vessels are performed, including scans that may use contrast agents or radioactive sugar. Some participants visit the research center for 1 to 4 days, while others have follow-up visits every 3 to 6 months, potentially continuing indefinitely. During the study, participants undergo clinical assessments, laboratory tests, and questionnaires. Blood, saliva, and cheek swab samples are collected for genetic and biomarker analysis. Imaging and nasal biopsies help explore disease mechanisms. Researchers monitor disease features and outcomes, aiming to develop better tools for diagnosis and prediction. Follow-up may last long term to observe disease course, with evaluations done by expert doctors.
CONDITIONS
Brief Title
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Who Can Participate
Age: 3Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Subjects who meet classification criteria for GPA, PAN, EGPA, GCA, TAK, or MPA
- Subjects with other suspected systemic or single-organ vasculitides
- Healthy volunteers able to provide consent or assent (for minors)
- Age 3 years or older
You will not qualify if you...
- Subjects younger than 3 years
- Active cancer, infection, or medical condition that warrants exclusion
- Unable to provide consent or assent
- Subjects with bleeding disorders or on certain blood thinners (coumadin, heparin, clopidogrel) excluded from nasal brushing or biopsy
- Healthy volunteers with autoimmune diseases or vasculitis
- Pregnant or breastfeeding volunteers
- Healthy volunteers taking certain blood thinners excluded from nasal brushing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Ongoing throughout the study duration
Participants undergo history, physical examination, laboratory evaluations, and may have additional organ-specific assessments, imaging studies, and biopsies as clinically indicated to study vasculitis.
Visits as needed depending on clinical evaluations
Long-term Monitoring
Duration - Up to several years
Participants are observed over time to evaluate the natural history, disease progression, and outcomes of idiopathic systemic vasculitis.
Periodic visits for follow-up assessments depending on disease status
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
S
Shanni Liu
P
Peter C Grayson, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
18 F-Fluorodeoxyglucose-Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis.
Peter C Grayson, Sara Alehashemi, Armin A Bagheri...
https://pubmed.ncbi.nlm.nih.gov/29145713Comparison of magnetic resonance angiography and 18F-fluorodeoxyglucose positron emission tomography in large-vessel vasculitis.
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri...
https://pubmed.ncbi.nlm.nih.gov/29666047Physician Global Assessment as a Disease Activity Measure for Relapsing Polychondritis.
Emily Rose, Marcela A Ferrada, Kaitlin A Quinn...
https://pubmed.ncbi.nlm.nih.gov/33544969Outcome Measures in Large Vessel Vasculitis: Relationship Between Patient-, Physician-, Imaging-, and Laboratory-Based Assessments.
Casey A Rimland, Kaitlin A Quinn, Joel S Rosenblum...
https://pubmed.ncbi.nlm.nih.gov/31785185Clinical symptoms and associated vascular imaging findings in Takayasu's arteritis compared to giant cell arteritis.
Despina Michailidou, Joel S Rosenblum, Casey A Rimland...
https://pubmed.ncbi.nlm.nih.gov/31649025