Actively Recruiting
Evaluation of New Biomarkers in the Identification of Unstable Carotid Plaque
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-03-20
200
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the link between circulating microRNAs (miRNAs) and carotid artery disease, focusing on both symptomatic and asymptomatic internal carotid artery stenosis (ICAS). The study aims to evaluate new biomarkers that could help identify unstable carotid plaques, which are associated with future cardiovascular events. This observational research is sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Participants in this study undergo carotid endarterectomy, a surgical procedure to remove plaque from the carotid artery. During the procedure, plaque samples are collected and analyzed for histological characteristics and miRNA expression. This helps researchers understand the relationship between plaque features and circulating miRNAs. Throughout the study, researchers measure miRNA levels 30 days after the procedure. Participants are monitored to assess the correlation between miRNA expression, plaque instability, and cardiovascular outcomes. This study involves adult participants with significant carotid artery stenosis who are referred for carotid endarterectomy. The overall goal is to improve detection and prediction of unstable plaques to better manage carotid artery disease.
CONDITIONS
Brief Title
Biomarkers and Unstable Carotid Plaque
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of significant internal carotid artery stenosis referred to carotid artery endarterectomy
- Age over 18 years
You will not qualify if you...
- Presence of significant internal carotid artery stenosis referred to carotid artery stenting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo carotid endarterectomy, including plaque removal and analysis.
1 surgical visit (in-person)
Duration - 30 days
Participants are monitored for miRNA levels and recovery following surgery.
Approximately 2 follow-up visits (in-person)
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, RM, Italy, 00167
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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