Evaluating Hydrochlorothiazide for Blood Pressure Control in Adults on Peritoneal Dialysis with High Blood Pressure

What this Trial Is About

Researchers are studying the blood pressure lowering effects of thiazide diuretics in patients who are on chronic peritoneal dialysis and have uncontrolled hypertension. This study is a prospective, single-center treatment-withdrawal crossover trial involving 10 participants. It focuses on evaluating changes in systolic and diastolic blood pressure over a 90-day period. Participants will first receive oral hydrochlorothiazide 25 mg once daily along with their standard treatment for 90 days. After this treatment phase, there will be a 14-day washout period without the drug, followed by a 90-day control period where no intervention is given. The study aims to compare blood pressure and other health markers during these periods. Throughout the study, participants will be monitored for changes in blood pressure, body weight, body composition using bio impedance spectroscopy, and urinary sodium excretion. The primary outcome is the change in systolic and diastolic blood pressure after 90 days. Safety and health status will be observed, and the total participation involves treatment and control phases separated by a washout period.

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients