Blood Pressure Treatment in ICU Patients with Subarachniodal Haemorrhage - Can Blood Pressure Be Used As a Surrogate Marker for Blood Flow

What this Trial Is About

This research investigates how blood pressure changes affect cerebral blood flow in patients who have had a subarachnoid hemorrhage (SAH), a serious type of stroke often requiring intensive care. The study focuses on patients with suspected or confirmed vasospasm, a complication that can occur days after the initial hemorrhage and impacts brain blood flow. Researchers aim to understand the relationship between blood pressure and brain nourishment during this critical period. Participants will undergo a process where blood pressure is increased by about 20-30% from their baseline using medication called norepinephrine while in the neuro-intensive care unit. Magnetic resonance imaging (MRI) techniques, including phase-contrast MRI and arterial spin labeling, will be used to measure cerebral blood flow before and after the blood pressure change. Blood pressure levels will be kept within safe clinical limits throughout the procedure. During the study, participants will have MRI scans to assess blood flow at baseline and after blood pressure elevation. All data will be recorded in the patients' medical records and analyzed later. The main outcome measured is cerebral blood flow within one hour of the intervention. The study is led by Umeå University and includes ongoing monitoring to ensure safety and accurate data collection during neuro-intensive care treatment.

Blood Pressure Treatment in ICU Patients with Subarachniodal Haemorrhage.