Study of Two Smell Training Methods to Improve Smell and Thinking in Adults 40 and Older with HIV

What this Trial Is About

Researchers are evaluating two types of smell training interventions in adults aged 40 and older living with HIV who have cognitive complaints. The study aims to determine if participants find the interventions acceptable and feasible, and whether these interventions improve their sense of smell and cognitive function. Participants are recruited primarily from a large HIVAIDS clinic and will be randomized into two groups. One group will receive conventional olfactory training using a kit with four different scents representing floral, resinous, aromatic, and fruity odors. They will sniff each scent twice daily for 8 weeks. The other group will use scented markers with various scents and choose four to sniff twice daily for 8 weeks. Both groups will keep daily diaries to record their experiences and any side effects. The study includes baseline and post-intervention assessments. Participants will visit the clinic for initial and post-intervention testing, which includes smell identification tests, cognitive assessments, and questionnaires about their health and quality of life. The study team will monitor adherence through diaries and weekly phone calls, and participants will receive reminders via text messages. The primary outcomes measured are feasibility and acceptability of the interventions, with additional assessments of olfactory and cognitive function. Total participation lasts about 8 weeks.

Boosting Olfactory and Sensory Training Study (BOOST)