Brain, Blood, and Clot or Tissue Registry to Study Cerebrovascular Diseases Including Stroke in Adults Undergoing Cerebrovascular Procedures

What this Trial Is About

Researchers are collecting and studying blood and tissue samples from patients undergoing cerebrovascular procedures to better understand stroke and other cerebrovascular diseases. This study includes up to 1000 adults, both male and female, who have or are suspected to have cerebrovascular disease. The aim is to identify biological markers and inflammatory cells that may help explain stroke pathology and support the development of improved treatments. Participants in this observational study will have biological samples collected during routine cerebrovascular surgeries or procedures. Samples include blood vessels, brain tissue, thrombus tissue, aneurysms, and plaques that would normally be discarded during care. Peripheral blood samples may also be taken before, immediately after, and at various times following the procedure, including during hospital stays, outpatient visits, and any readmissions. During the study, researchers will gather detailed medical and medication histories, perform physical exams, and record stroke severity and other clinical scores as part of standard care. The primary outcome measured is blood pH as an indicator of acidbase balance in blood samples, correlated with the time between stroke onset and vessel reopening. Participants involvement may last several years with ongoing sample collection and follow-up assessments to support research on stroke and cerebrovascular disease.

Brain, Blood And Clot or Tissue Registry And Collaboration