Actively Recruiting
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
Led by University of California, Los Angeles · Updated on 2025-10-02
42
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating brain imaging biomarkers that might predict how patients with chronic low back pain respond to spinal cord stimulation (SCS). The study focuses on understanding brain connectivity, especially in the subgenual cingulate region, to help identify who may benefit from SCS treatment. This research involves 42 patients undergoing SCS as part of their usual care over a two-year period. Participants will have two visits during the study. At the first visit, they will undergo brain imaging and related assessments before starting SCS treatment. The second visit occurs two weeks after SCS, possibly conducted remotely, to complete final assessments. No additional imaging beyond the research protocol is required as part of their standard care. Throughout the study, researchers will measure changes in pain and mood using various scales such as the Visual Analog Scale (VAS), Hamilton Depression Rating Scale (HAMD-17), McGill Pain Questionnaire (MPQ), and Pain Anxiety Symptoms Scale (PASS) from baseline to two weeks after treatment. The study aims to better understand brain responses to SCS and improve patient selection, with all procedures completed within a short timeframe.
CONDITIONS
Brief Title
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 21 years of age or older at the time of consent
- Recommended to undergo a spinal cord stimulation trial for chronic back pain by a pain management physician
- Chronic low back pain lasting 12 weeks or longer despite prior treatments
- Signed informed consent form approved by the Institutional Review Board
You will not qualify if you...
- Women who are not using adequate contraception, are pregnant, breastfeeding, or intend to become pregnant during the study
- Previous spinal cord stimulation trial or implanted active devices for pain treatment or cardiac devices
- Current alcohol or illicit drug abuse
- Contraindications to MRI or need for repeated body MRIs
- Presence of cardiac pacemakers, implantable medication pumps, intracranial implants, or other stimulators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 weeks
Participants undergo brain imaging to identify biomarkers related to spinal cord stimulation response.
1 to 2 visits depending on imaging requirements
Duration - 2 weeks
Participants are observed to assess changes in pain and mood over time without receiving active intervention as part of the study.
1 follow-up visit at 2 weeks
Trial Site Locations
Total: 1 location
1
University of California Los Angeles
Los Angeles, California, United States, 90067
Actively Recruiting
Research Team
M
Meskereen Tolossa
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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