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Brain Imaging to Find Biomarkers Predicting Response to Spinal Cord Stimulation in Adults with Chronic Low Back Pain
Led by University of California, Los Angeles · Updated on 2025-10-02
42
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating brain imaging biomarkers that might predict how patients with chronic low back pain respond to spinal cord stimulation SCS. The study focuses on understanding brain connectivity, especially in the subgenual cingulate region, to help identify who may benefit from SCS treatment. This research involves 42 patients undergoing SCS as part of their usual care over a two-year period. Participants will have two visits during the study. At the first visit, they will undergo brain imaging and related assessments before starting SCS treatment. The second visit occurs two weeks after SCS, possibly conducted remotely, to complete final assessments. No additional imaging beyond the research protocol is required as part of their standard care. Throughout the study, researchers will measure changes in pain and mood using various scales such as the Visual Analog Scale VAS, Hamilton Depression Rating Scale HAMD-17, McGill Pain Questionnaire MPQ, and Pain Anxiety Symptoms Scale PASS from baseline to two weeks after treatment. The study aims to better understand brain responses to SCS and improve patient selection, with all procedures completed within a short timeframe.
CONDITIONS
Brief Title
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
Research Team
M
Meskereen Tolossa
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