Actively Recruiting
Assessing the Predictability of Brain, Psychological and Epigenetic Determinants for Optimizing the Treatment of Chronic Low Back Pain
Led by Université de Sherbrooke · Updated on 2023-09-13
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic low back pain (CLBP) affects many people and can be caused by various arthritis conditions. Researchers aim to better understand how the brain contributes to CLBP by studying its structure and function. This observational study seeks to improve diagnosis and treatment by exploring brain properties and psychological and epigenetic factors in people with CLBP. Participants are individuals living with CLBP who will undergo facet thermal ablation treatment. The study does not provide any intervention itself but observes changes before and after the treatment. Brain scans and other assessments will be conducted at multiple time points: 1 week, 2 months, and 4 months before treatment, as well as 2 months and 4 months after treatment. During the study, participants will have brain imaging to measure grey matter volume, blood-oxygen levels, and white matter properties, along with assessments of brain arteries and veins. Researchers will also track changes in pain severity, psychological scores, functional abilities, and other health measures over time. These evaluations help to understand treatment effects on brain and pain-related factors. The study period spans several months with scheduled monitoring before and after treatment.
CONDITIONS
Brief Title
Brain, Psychological and Epigenetic Determinants for Optimizing the Treatment of Chronic Low Back Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have low back pain lasting 6 months or more, with or without pain radiating to legs or neck
- Have positive medial branch blocks indicating pain from lumbar facet joints
- Have average pain intensity of 3 or higher out of 10 in the 24 hours before the first visit
- Have pain mainly located in the lower back
- Are between 18 and 75 years old
You will not qualify if you...
- Have had less than three months of pain relief after selective thermoablation of medial lumbar branches by radiofrequency
- Have neurological, cardiovascular, or pulmonary disorders
- Have another pain syndrome besides low back pain
- Have a history of back surgery
- Have had a corticosteroid injection in the past year
- Are currently pregnant or plan to become pregnant during the study
- Have contraindications to Magnetic Resonance Imaging (MRI)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 months before treatment
Participants undergo brain imaging and assessments to evaluate brain structure, function, and epigenetic markers before treatment.
3 visits (1 week, 2 months, and 4 months before treatment)
Duration - Day of treatment
Participants receive facet thermal ablation treatment for chronic low back pain as part of their routine care.
1 treatment visit (in-person)
Duration - 4 months after treatment
Participants are monitored with brain imaging and assessments to evaluate changes after treatment.
2 visits (2 months and 4 months post treatment)
Trial Site Locations
Total: 1 location
1
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS)
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
Research Team
P
Pascal Tétreault, PhD
M
Marylie Martel, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here