Study of Cognitive Training and Brain Stimulation for Cognitive Symptoms After Long COVID in Adults Aged 25 to 60

What this Trial Is About

Researchers are evaluating two interventions to manage cognitive symptoms resulting from long COVID. This experimental study will compare a Categorization Program CP training combined with either active transcranial direct current stimulation tDCS or sham tDCS. The study aims to better understand how these treatments affect cognition in individuals experiencing post-COVID cognitive difficulties. Participants will be randomly assigned to one of two groups the experimental group receiving active tDCS combined with the CP cognitive training, and the control group receiving sham tDCS with CP training. Both interventions involve 15 one-hour sessions over three weeks, with two tDCS sessions plus cognitive training delivered during each session in the experimental group, and cognitive training with sham tDCS in the control group. The study uses updated neuroimaging and neuropsychological assessments to evaluate changes before and after treatment. During the study, participants will undergo diagnostic protocols including neuroimaging and neuropsychological tests. Functional near-infrared spectroscopy fNIRS will be used before and after the intervention to assess brain function. Outcome measures include tests from the Categorization Program, probe tasks at various points during treatment, and quality of life and dysexecutive questionnaires. The total intervention lasts six weeks, with assessments conducted pre- and post-training to monitor cognitive and quality of life changes.

Brain Research and Integrative Neuroscience Network for COVID-19