Actively Recruiting
Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN)
Led by University of Cyprus · Updated on 2024-12-06
70
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two interventions to manage cognitive symptoms resulting from long COVID. This experimental study will compare a Categorization Program (CP) training combined with either active transcranial direct current stimulation (tDCS) or sham tDCS. The study aims to better understand how these treatments affect cognition in individuals experiencing post-COVID cognitive difficulties. Participants will be randomly assigned to one of two groups: the experimental group receiving active tDCS combined with the CP cognitive training, and the control group receiving sham tDCS with CP training. Both interventions involve 15 one-hour sessions over three weeks, with two tDCS sessions plus cognitive training delivered during each session in the experimental group, and cognitive training with sham tDCS in the control group. The study uses updated neuroimaging and neuropsychological assessments to evaluate changes before and after treatment. During the study, participants will undergo diagnostic protocols including neuroimaging and neuropsychological tests. Functional near-infrared spectroscopy (fNIRS) will be used before and after the intervention to assess brain function. Outcome measures include tests from the Categorization Program, probe tasks at various points during treatment, and quality of life and dysexecutive questionnaires. The total intervention lasts six weeks, with assessments conducted pre- and post-training to monitor cognitive and quality of life changes.
CONDITIONS
Brief Title
Brain Research and Integrative Neuroscience Network for COVID-19
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Reported cognitive difficulties due to COVID-19 infection
- Meet World Health Organization criteria for Long COVID
- Female participants aged between 25 and 60 years
You will not qualify if you...
- Significant history of neuropsychiatric conditions prior to contracting COVID-19
- History of neurological conditions such as traumatic brain injury, stroke, or multiple sclerosis before COVID-19 infection
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 2 weeks
Participants undergo neuroimaging and neuropsychological assessments before starting the intervention.
1 to 2 visits
Duration - 3 weeks
Participants receive 15 one-hour sessions over three weeks combining cognitive training with either active or sham tDCS according to their group assignment.
15 sessions distributed over 3 weeks
Duration - Up to 3 weeks post-treatment
Participants complete neuropsychological performance tests, quality of life measures, and functional near-infrared spectroscopy assessments after the intervention.
Visits at 2 weeks, 3 weeks, and 6 weeks after starting training
Trial Site Locations
Total: 1 location
1
University of Cyprus
Nicosia, Cyprus, Cyprus, 1678
Actively Recruiting
Research Team
F
Fofi Constantinidou, Ph.D.
E
Eleni Michael
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
2
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