Actively Recruiting
Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
Led by University of Minnesota · Updated on 2026-03-27
102
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded during standing balance reactions, as well as biological blood samples for genomic analysis.
CONDITIONS
Official Title
Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age within the following 3 group age ranges: 21-30 years old; 40-55 years old; 65-95 years old
- No major orthopedic disability
- Cognitively normal (MoCA score 6gt;= 26/30 in older adult group)
- Vision of 20/40 or better with or without corrective lenses
- Ability to consent and communicate with researchers
- English speaking
- Ability to stand for 3 minutes and walk 10 meters with or without an assistive device and without the assistance of another person
You will not qualify if you...
- Insulin-dependent diabetes
- Peripheral neuropathy
- Myocardial infarction or symptoms of coronary artery disease within 2 years
- Congestive heart failure or class IV heart failure
- Any significant sensory impairment affecting balance or cognition, including visual, vestibular, or auditory impairments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
J
Jacqueline Palmer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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