Actively Recruiting
Breast Cancer Exercise Intervention Study (BREXINT)
Led by National Cancer Centre, Singapore · Updated on 2025-09-05
2156
Participants Needed
3
Research Sites
260 weeks
Total Duration
On this page
Sponsors
N
National Cancer Centre, Singapore
Lead Sponsor
S
Singapore Cancer Society
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the effects of a 24-week exercise program on patients with early-stage and locally advanced breast cancer who have undergone curative breast surgery and completed any chemotherapy or radiotherapy. This randomized controlled study involves 2156 female patients aged 21 years or older, stratified by location, menopausal status, hormone receptor status, and body composition. The study aims to monitor disease-free survival and overall survival up to five years. The exercise program includes aerobic and muscle strength training sessions three times weekly for 24 weeks, totaling 72 sessions. The first nine sessions are supervised in person by physiotherapists, followed by 63 sessions supervised remotely or at gyms by trainers. Aerobic exercise involves 20-minute brisk walks or jogs on a treadmill targeting 50% to 70% of each participant's VO2max, while strength training includes circuit resistance exercises focusing on major muscle groups. Participants will undergo regular monitoring including blood collection at baseline, 8, 16, 24, and 52 weeks, then annually for four years. Assessments include cardiorespiratory fitness, muscle strength, daily physical activity, body composition, quality of life questionnaires, and food diaries. The study includes two groups: the exercise intervention group and a usual care control group, with disease-free survival as the primary outcome measured over five years.
CONDITIONS
Brief Title
Breast Cancer Exercise Intervention Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically or cytologically proven stage 1, 2, or 3 breast cancer
- Patients who have undergone curative breast surgery
- Patients who have received (neo)adjuvant chemotherapy (if given) and/or radiotherapy (if given)
- Females aged 21 years and older
- Within 8 weeks from breast surgery or last adjuvant chemotherapy or radiotherapy session, whichever is latest
You will not qualify if you...
- Cardiovascular, respiratory, or musculoskeletal problems that prevent moderate physical activity
- Major medical problems deemed unsuitable for enrollment by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 weeks
Participants in the exercise group attend aerobic and strength training sessions three times per week for 24 weeks. Participants in the control group receive usual care without the exercise intervention.
3 sessions per week
Duration - Up to 5 years
Participants are monitored for disease-free and overall survival up to 5 years after treatment.
Blood collection at baseline, 8, 16, 24, 52 weeks, then annually for 4 years; periodic quality of life questionnaires and food diary maintenance
Trial Site Locations
Total: 3 locations
1
National University Hospital
Singapore, Singapore, 119074
Actively Recruiting
2
National Cancer Centre
Singapore, Singapore, 168583
Actively Recruiting
3
Singapore General Hospital
Singapore, Singapore, 169608
Actively Recruiting
Research Team
D
Dr Elaine LIM, MD, PhD
C
Catherine CELES
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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