Actively Recruiting
Breathing Patterns in Infants Before and After Extubation
Led by Christiana Care Health Services · Updated on 2026-04-21
30
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate breathing patterns in premature infants who are intubated and admitted to the Christiana Care Neonatal Intensive Care Unit. The study focuses on comparing work of breathing indices before and after extubation, as well as assessing how well these indices predict extubation failure compared to routine spontaneous breathing tests. This observational pilot study addresses the need for better tools to determine when babies are ready to have their breathing tubes removed. The study will observe infants' breathing efforts using respiratory inductive plethysmography (RIP), which involves placing soft elastic cloth bands around the baby's chest and abdomen to measure how these areas work together during breathing. Measurements will be taken before, during, and after the routine spontaneous breathing trial and extubation, if the medical team decides to remove the breathing tube. There is only one group in this study: premature infants who are intubated. Participants will be closely monitored while these breathing measurements are collected over about 25 minutes before and after extubation. Researchers will track the babies' vital signs and breathing work to compare with standard tests. The main outcomes include the work of breathing indices and their ability to predict extubation success or failure. The study will follow infants up to six months of age, with no intervention beyond observation and measurement of breathing patterns.
CONDITIONS
Brief Title
Breathing Patterns in Infants Before and After Extubation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premature infants born at 32 weeks gestation or earlier who are intubated
- Medical team is evaluating the infant for extubation readiness
You will not qualify if you...
- Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of respiratory inductive plethysmography measurements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 25 minutes before and after extubation
Participants will have soft elastic cloth bands placed around their chest and abdomen to measure work of breathing before, during, and after a spontaneous breathing trial and extubation.
1 to 2 in-person assessments depending on extubation timing
Trial Site Locations
Total: 1 location
1
ChristianaCare Health Services, Inc.
Newark, Delaware, United States, 19718
Actively Recruiting
Research Team
K
Kelley Z. Kovatis, MD
A
Amy B Mackley
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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