Actively Recruiting
Breathing Rescue for SUDEP Prevention (BreatheS)
Led by The University of Texas Health Science Center, Houston · Updated on 2025-06-18
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying people with focal epilepsy to better understand the brain networks that control breathing and to find brain areas and stimulation methods that might help prevent breathing failure caused by seizures. This study aims to identify precise brain functions related to respiration using electrical stimulation techniques. Participants will perform various breathing tasks such as normal breathing through the nose or mouth, breathing while resting, changing their breathing rate, and breath counting. Brain mapping will be done using electrical stimulation with specialized equipment to locate areas involved in breathing. This procedure uses a neural function measuring system with a brain stimulation device during the hospital stay. During the study, researchers will monitor breathing changes using EEG signals, thoracoabdominal belts, nasal/oral pressure sensors, pulse oximetry, and carbon dioxide measurements before and during stimulation sessions. They will measure changes in breathing rate, depth, and minute ventilation. The study involves an inpatient stay in an epilepsy monitoring unit where participants undergo brain recording and stimulation to assess outcomes related to breathing function.
CONDITIONS
Brief Title
Breathing Rescue for SUDEP Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of intractable focal epilepsy
- Admitted to the Epilepsy Monitoring Unit (EMU) for intracranial subdural strips, grids, or depth electrode placement study (invasive video-EEG)
- Adults aged 18 years or older
You will not qualify if you...
- Respiratory, cardiac, or cerebrovascular disease
- Pregnancy
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At least 2 hours on the day of the intervention
Participants perform breathing tasks including normal breathing, controlled breathing rates, and breath counting while brain stimulation is applied to map areas involved in breathing function.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
N
Nuria L Lecumberri, MD,PhD
S
Sandhya Rani, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here