High-frequency neural activity and human cognition: past, present and possible future of intracranial EEG research.
Jean-Philippe Lachaux, Nikolai Axmacher, Florian Mormann...
https://pubmed.ncbi.nlm.nih.gov/22750156Actively Recruiting
Age: 18Years - 65Years
All Genders
ID03644732
Atlas of Human Cognition by SEEG for Epilepsy Presurgical Assessment
Led by University Hospital, Grenoble · Updated on 2024-03-19
200
Participants Needed
4
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with refractory or focal epilepsy who undergo pre-surgical evaluation using Stereoelectroencephalography (SEEG). The goal is to create a detailed brain atlas of human cognition by collecting brain recordings taken during cognitive tasks performed as part of routine clinical care. This atlas will provide high temporal and spatial resolution data to better understand how epilepsy and epilepsy surgery affect cognitive functions. Participants will have intracerebral electrodes implanted as part of their invasive SEEG assessment to locate epileptogenic zones and evaluate cognitive risks before surgery. During this procedure, brain activity is recorded while patients perform cognitive tasks. This study uses Dynamic Spectral Imaging (ISD) to map gamma oscillations in the brain, which are linked to complex cognitive functions. Behavioral and neuropsychological data may also be collected after surgery. During the study, participants complete cognitive tasks while SEEG signals are visually and quantitatively analyzed over about three weeks. Researchers measure brain activity through functional mapping and record composite behavioral data. The study monitors patients’ intellectual capacity to comply with cognitive testing and collects detailed brain function data to improve understanding of epilepsy's impact on cognition. Participation lasts through the clinical evaluation and data collection periods.
CONDITIONS
Brief Title
Atlas of Human Cognition by SEEG (MAPCOG-SEEG)
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Drug-resistant focal epilepsy
- Justified SEEG exploration in the context of presurgical assessment of epilepsy
- Written non-opposition to study participation
- Intellectual capacities compatible with compliance in cognitive tasks
You will not qualify if you...
- Patients under legal protection or deprived of liberty due to judicial or administrative decisions
- Inability to collect exposure information (recent arrival in France, foreign language barriers)
- Pregnant women (contraindication to SEEG exploration)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Approximately 3 weeks
Participants undergo invasive exploration by implantation of intracerebral electrodes during SEEG to evaluate epileptogenic zones and cognitive functions through brain mapping.
Multiple visits for SEEG recording and functional brain mapping
Long-term Monitoring
Duration - Up to 3 weeks
Participants' behavioral and neuropsychological data are collected postsurgically to assess cognitive outcomes.
Visits as needed for behavioral and neuropsychological assessments
Trial Site Locations
Total: 4 locations
1
University Hospital, Grenoble
Grenoble, France, 38043
Actively Recruiting
2
CHRU Nancy
Nancy, France
Actively Recruiting
3
Hôpital Ste Anne
Paris, France, 75014
Actively Recruiting
4
CHU Rennes
Rennes, France
Actively Recruiting
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Research Team
P
Philippe Kahane, MD/PhD
M
Marcela Perrone-Bertolotti, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
What do patients with epilepsy tell us about language dynamics? A review of fMRI studies.
Monica Baciu, Marcela Perrone-Bertolotti
https://pubmed.ncbi.nlm.nih.gov/25741734From intentions to actions: Neural oscillations encode motor processes through phase, amplitude and phase-amplitude coupling.
Etienne Combrisson, Marcela Perrone-Bertolotti, Juan Lp Soto...
https://pubmed.ncbi.nlm.nih.gov/27915117Efficient "pop-out" visual search elicits sustained broadband γ activity in the dorsal attention network.
Tomas Ossandón, Juan R Vidal, Carolina Ciumas...
https://pubmed.ncbi.nlm.nih.gov/22399764Turning visual shapes into sounds: early stages of reading acquisition revealed in the ventral occipitotemporal cortex.
M Perrone-Bertolotti, J R Vidal, L de Palma...
https://pubmed.ncbi.nlm.nih.gov/24370818How silent is silent reading? Intracerebral evidence for top-down activation of temporal voice areas during reading.
Marcela Perrone-Bertolotti, Jan Kujala, Juan R Vidal...
https://pubmed.ncbi.nlm.nih.gov/23223279