Atlas of Human Cognition Using SEEG in Adults with Drug-Resistant Focal Epilepsy

What this Trial Is About

Researchers are studying patients with refractory or focal epilepsy who undergo pre-surgical evaluation using Stereoelectroencephalography SEEG. The goal is to create a detailed brain atlas of human cognition by collecting brain recordings taken during cognitive tasks performed as part of routine clinical care. This atlas will provide high temporal and spatial resolution data to better understand how epilepsy and epilepsy surgery affect cognitive functions. Participants will have intracerebral electrodes implanted as part of their invasive SEEG assessment to locate epileptogenic zones and evaluate cognitive risks before surgery. During this procedure, brain activity is recorded while patients perform cognitive tasks. This study uses Dynamic Spectral Imaging ISD to map gamma oscillations in the brain, which are linked to complex cognitive functions. Behavioral and neuropsychological data may also be collected after surgery. During the study, participants complete cognitive tasks while SEEG signals are visually and quantitatively analyzed over about three weeks. Researchers measure brain activity through functional mapping and record composite behavioral data. The study monitors patients intellectual capacity to comply with cognitive testing and collects detailed brain function data to improve understanding of epilepsys impact on cognition. Participation lasts through the clinical evaluation and data collection periods.

Atlas of Human Cognition by SEEG (MAPCOG-SEEG)