Actively Recruiting
Home-based, Digitally Delivered Breathing Training in People With Non-cystic Fibrosis Bronchiectasis: A Randomized Control Trial
Led by Mayo Clinic · Updated on 2026-01-06
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a home-based, health coach supported breathing and respiratory muscle training program for people with non-cystic fibrosis bronchiectasis (non-CFB). The study aims to see if this program improves exercise ability, lung and breathing muscle function, and overall clinical status. The trial is a randomized control design led by the Mayo Clinic, focusing on adults aged 21 to 80 who have stable non-CFB. Participants will be assigned randomly to one of two groups. One group receives standard physician-directed pulmonary rehabilitation care, while the other group receives the same standard care plus an 8-week home-based program using the LungTrainers device. This program involves breathing exercises 3-5 days per week, guided by a health coach, with sessions lasting 20-30 minutes or divided into shorter periods. The LungTrainers device provides resistance during exhalation to strengthen respiratory muscles. During the study, participants will undergo assessments at the start and after 8 weeks, including a six-minute walk test and maximal exercise tests to measure oxygen uptake and exercise capacity. Additional evaluations will monitor lung function, breathing muscle strength, diaphragm movement, breathlessness scales, quality of life questionnaires, and functional assessments. The study will track changes in these measurements to understand the program's impact on participants' respiratory health and exercise capacity.
CONDITIONS
Brief Title
Breathing Training and Exercise Capacity in Non-CFB
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mayo Clinic patient with confirmed diagnosis of Non-Cystic Fibrosis Bronchiectasis (non-CFB) based on clinical history and tests
- Clinically stable with no exacerbation or therapy changes in the past 3 weeks
- Able and willing to provide informed consent to participate in the study
- Aged between 21 and 80 years
You will not qualify if you...
- Significant coexisting disease, neurological conditions, or orthopedic complications affecting exercise ability
- Advanced heart failure
- Current use of antibiotics
- Acute exacerbation(s) within 3 weeks before study start
- Participation in a pulmonary rehabilitation program within the last 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants in the experimental group complete an 8-week home-based breathing and respiratory muscle training program using the LungTrainers device, guided by a health coach. Participants in the control group receive standard physician-directed pulmonary rehabilitation care.
Weekly visits for progress assessments and guidance
Trial Site Locations
Total: 1 location
1
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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