Actively Recruiting
Bronchiectasis Phenotype Identification Model for Non-Cystic Fibrosis Bronchiectasis Using Latent Class Trajectory Analysis
Led by Assiut University · Updated on 2026-05-20
750
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating a method called the Bronchiectasis Phenotype Identification Model (BPIM) to classify different types of bronchiectasis in adults with non-cystic fibrosis bronchiectasis (NCFB). This observational study uses advanced data analysis to identify patterns in disease progression and translate these into a model that can predict disease subtypes based on initial patient data. The study is conducted within the Assiut University bronchiectasis translational research platform and focuses on improving understanding of bronchiectasis phenotypes without assigning any treatments or interventions. The study involves two groups of adult participants with confirmed NCFB: a development cohort and a validation cohort. The development cohort is used to analyze longitudinal disease data and train the BPIM to recognize distinct bronchiectasis phenotypes, while the validation cohort is used to test the model's accuracy without any adjustments. All participants continue to receive standard clinical care from their physicians throughout the study. No experimental treatment or changes in management are made by the study protocol. Participants will undergo routine clinical assessments including functional tests, oxygenation evaluations, radiological imaging, and inflammatory marker measurements at baseline and during follow-up visits up to 12 months. Researchers will measure how accurately the BPIM classifies bronchiectasis phenotypes compared to established analytical methods. The study also tracks disease exacerbations, hospital admissions, and other clinical outcomes. Participants' involvement includes regular assessments to support data collection for model development and validation over the study period.
CONDITIONS
Brief Title
Bronchiectasis Phenotype Identification Model
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Diagnosis of non-cystic fibrosis bronchiectasis (NCFB) based on clinical assessment and high-resolution computed tomography (HRCT)
- Patients attending outpatient clinics, inpatient wards, or respiratory follow-up services at Assiut University Hospitals during the study enrollment period
- Patients suitable for baseline disease-signature assessment within the Bronchiectasis Phenotype Identification Model (BPIM) framework
- Ability to undergo routine clinical, functional, radiological, oxygenation, and inflammatory assessment according to the study protocol
- Ability to complete planned longitudinal follow-up required for latent class trajectory analysis (LCTA) and Bronchiectasis Phenotype Identification Model (BPIM) validation
- Written informed consent obtained from the patient or legal representative
You will not qualify if you...
- Cystic fibrosis-related bronchiectasis
- Traction bronchiectasis due to advanced fibrotic interstitial lung disease as the dominant respiratory diagnosis
- Active pulmonary tuberculosis at enrollment
- Active nontuberculous mycobacterial pulmonary disease requiring specific treatment at enrollment
- Active malignancy or terminal non-respiratory illness expected to prevent planned follow-up
- Acute life-threatening illness preventing safe enrollment or reliable baseline assessment
- Recent major thoracic surgery or acute thoracic trauma interfering with baseline respiratory assessment
- Inability to complete required baseline disease-signature assessment according to the Bronchiectasis Phenotype Identification Model (BPIM) protocol
- Inability or unwillingness to complete planned longitudinal follow-up
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline to 12 months follow-up
Participants who undergo routine care are observed. Measurements are collected before and after routine healthcare to identify bronchiectasis phenotypes and validate the predictive model over time.
Periodic visits during 12 months follow-up
Trial Site Locations
Total: 1 location
1
Assiut university-Faculty of Medicine
Asyut, Assiut Egypt, Egypt, 71515
Actively Recruiting
Research Team
A
Ahmad M Shaddad, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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