Actively Recruiting
GEMINI - Cancer Genetic Testing in Ethnic Populations at Mayo Clinic
Led by Mayo Clinic · Updated on 2026-04-02
1800
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study the presence of genetic mutations linked to cancer in patients from diverse ethnic backgrounds who visit Mayo Clinic Arizona and Mayo Clinic Florida cancer clinics. By examining individuals and families at risk, the study seeks to identify cancer genes and those who may be at risk, potentially enabling personalized cancer risk assessment and screening in these ethnic groups. The study focuses on various solid tumor cancers, including breast, gastrointestinal, skin, brain, and others. Participants provide a blood or saliva sample for genetic testing to detect pathogenic germline mutations. The study compares the mutation detection rates from this testing to traditional guideline-based approaches, such as those from the National Comprehensive Cancer Network (NCCN). This testing is integrated as part of standard oncology care for patients. During the study, participants undergo sample collection and genetic analysis. Researchers review patient charts to assess how genetic testing affects treatment and targeted cancer prevention. The main measures include the prevalence of mutations within different cancer types, the detection rate of mutations, and the impact of testing on therapy management. The study completion is expected within two years, and participants' involvement includes providing samples and allowing medical record review.
CONDITIONS
Brief Title
Cancer Genetic Testing in Ethnic Populations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients at least 18 years of age
- Diagnosed with any solid tumor cancer including gastrointestinal, breast, gynecological, genitourinary, skin, central nervous system, brain, head/neck, musculoskeletal, or cancer of unknown primary
- Presenting to Mayo Clinic Arizona or Florida for clinical management and treatment
- Self-identified as belonging to various ethnic populations including Hispanic/Latino, Native American/Alaskan, African American, Asian, or European
- Feasible to collect blood samples for genetic testing
- Agreed to participate and signed informed consent
You will not qualify if you...
- Prior germline genetic testing with a 40+ gene panel at Mayo Clinic within the last 24 months
- Past or current history of hematological cancers such as leukemias or multiple myeloma
- History of bone marrow transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for biospecimen collection
Duration - Up to 2 years
Participants who undergo routine cancer care are observed to determine the prevalence of genetic mutations and assess the impact of genetic testing as part of standard oncology care.
No additional study visits beyond routine clinical care
Trial Site Locations
Total: 2 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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