Cancer Genetic Testing Study in Adults From Diverse Ethnic Groups at Mayo Clinic

What this Trial Is About

This research aims to study the presence of genetic mutations linked to cancer in patients from diverse ethnic backgrounds who visit Mayo Clinic Arizona and Mayo Clinic Florida cancer clinics. By examining individuals and families at risk, the study seeks to identify cancer genes and those who may be at risk, potentially enabling personalized cancer risk assessment and screening in these ethnic groups. The study focuses on various solid tumor cancers, including breast, gastrointestinal, skin, brain, and others. Participants provide a blood or saliva sample for genetic testing to detect pathogenic germline mutations. The study compares the mutation detection rates from this testing to traditional guideline-based approaches, such as those from the National Comprehensive Cancer Network NCCN. This testing is integrated as part of standard oncology care for patients. During the study, participants undergo sample collection and genetic analysis. Researchers review patient charts to assess how genetic testing affects treatment and targeted cancer prevention. The main measures include the prevalence of mutations within different cancer types, the detection rate of mutations, and the impact of testing on therapy management. The study completion is expected within two years, and participants involvement includes providing samples and allowing medical record review.

Cancer Genetic Testing in Ethnic Populations