Study of Heart Amyloid Deposits and Heart Function in People Being Tested for Alzheimers Disease Using PET and MRI Scans

What this Trial Is About

Researchers are investigating the possible shared causes of cardiac amyloidosis and Alzheimers disease, both involving amyloid deposits. This observational study uses Positron Emission Tomography PET scans with amyloid tracers, typically used for Alzheimers imaging, to also examine amyloid deposits in the heart. The goal is to improve diagnosis methods for both conditions by exploring their connection. Participants are patients clinically referred for cerebral amyloid PET scans to clarify an Alzheimers diagnosis. In addition to the brain PET scan, the study adds cardiac PETMRI imaging without extra substances or radiation. Participants also receive a transthoracic echocardiogram with strain analysis and a 12-lead electrocardiogram EKG as part of a comprehensive diagnostic assessment. During the study, each participant undergoes clinical dementia evaluation along with the imaging tests. Researchers observe the frequency of cardiac amyloid deposits overall and in relation to disease stages over about one year. The study includes regular heart and brain assessments to monitor amyloid presence and heart function, aiming to better understand their link in Alzheimers disease.

Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease