Actively Recruiting
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
Led by University Hospital, Essen · Updated on 2025-09-04
15
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.
CONDITIONS
Official Title
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
- No contraindications to undergo an MRI examination
- No contraindications to undergo an Amyloid PET scan
You will not qualify if you...
- Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
- Patients with pronounced cardiac preconditions
- Pregnant and breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Essen
Essen, North Rhine-Westphalia, Germany, 45147
Actively Recruiting
Research Team
D
David Kersting, MD PhD
CONTACT
S
Stephan Settelmeier, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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