Resting End-Tidal Carbon Dioxide Predicts Respiratory Complications in Patients Undergoing Thoracic Surgical Procedures.
Kristian Brat, Zuzana Tothova, Zdenek Merta...
https://pubmed.ncbi.nlm.nih.gov/27496629Actively Recruiting
Age: 18Years +
All Genders
ID06702059
Cardiopulmonary Exercise Testing to Predict Post-operative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery
Led by St. Anne's University Hospital Brno, Czech Republic · Updated on 2025-05-15
130
Participants Needed
2
Research Sites
13 weeks
Total Duration
On this page
Sponsors
S
St. Anne's University Hospital Brno, Czech Republic
Lead Sponsor
C
Centre of Cardiovascular and Transplantation Surgery, Czech Republic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the use of cardiopulmonary exercise testing (CPET) to predict complications after coronary artery bypass graft (CABG) surgery. CPET is considered a gold standard for evaluating high-risk patients before major surgery, but its role in heart surgery is not well understood. The study focuses on certain exercise parameters, including the partial pressure of end-tidal carbon dioxide (PETCO2) and the VE/VCO2 slope, which may help predict mortality and complications after surgery. Patients scheduled for CABG surgery will undergo CPET before their operation. This diagnostic test involves measuring how well the heart and lungs perform during exercise. After surgery, researchers will monitor the patients for any cardiovascular or pulmonary complications within 30 days. The study will also track the length of hospital and intensive care stays during this period. Participants will be closely observed throughout the study period, with data collected from the CPET and post-operative monitoring. Researchers will evaluate the occurrence of complications within 30 days after surgery to assess how well CPET predicts outcomes. This observational study will help determine if CPET parameters can improve risk assessment for patients undergoing heart surgery.
CONDITIONS
Brief Title
Cardiopulmonary Exercise Testing in Cardiosurgery Patients
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients scheduled for coronary artery bypass graft surgery
You will not qualify if you...
- Unable to perform cardiopulmonary exercise testing
- Off-pump revascularization
- Surgery without full sternotomy
- Previous cardiac surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 to 2 weeks
Participants undergo pre-operative cardiopulmonary exercise testing to assess fitness before surgery.
1 visit (in-person)
Long-term Monitoring
Duration - 30 days post-operation
Participants are monitored for post-operative pulmonary and cardiovascular complications and hospital stay outcomes.
Regular monitoring during hospital stay and up to 30 days after surgery
Trial Site Locations
Total: 2 locations
1
Centre of Cardiovascular and Transplantation Surgery
Brno, Czech Republic, Czechia, 60200
Actively Recruiting
2
St. Anne's University Hospital in Brno
Brno, Czech Republic, Czechia, 61200
Active, Not Recruiting
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Research Team
I
Ivan Cundrle, prof., M.D.
M
Marek Lukes, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study.
Ivan Cundrle, Zdenek Merta, Monika Bratova...
https://pubmed.ncbi.nlm.nih.gov/36891072Exercise-induced myocardial dysfunction detected by cardiopulmonary exercise testing is associated with increased risk of mortality in major oncological colorectal surgery.
Jason Mann, Murray Williams, Jonathan Wilson...
https://pubmed.ncbi.nlm.nih.gov/32085879Minute ventilation-to-carbon dioxide output (VE/VCO2) slope is the strongest predictor of respiratory complications and death after pulmonary resection.
Alessandro Brunelli, Romualdo Belardinelli, Cecilia Pompili...
https://pubmed.ncbi.nlm.nih.gov/22560968Prediction of Postoperative Complications: Ventilatory Efficiency and Rest End-tidal Carbon Dioxide.
Kristian Brat, Pavel Homolka, Zdenek Merta...
https://pubmed.ncbi.nlm.nih.gov/35074321Cardiopulmonary exercise testing and its application.
Khaled Albouaini, Mohaned Egred, Albert Alahmar...
https://pubmed.ncbi.nlm.nih.gov/17989266