Study of Brain Oxygen Metabolism and Blood Flow in Children and Adults Ages 3 to 50

What this Trial Is About

Researchers are studying how changes in blood flow and metabolism affect brain development in children and adults up to 50 years old. The study focuses on brain blood flow regulation, especially how blood vessels expand and contract to meet the brains oxygen needs. It aims to identify imaging markers that show brain tissue under stress and at risk for injury, particularly in conditions like sickle cell disease and after strokes. Participants will undergo magnetic resonance imaging MRI using specialized sequences to measure cerebral blood flow CBF, oxygen extraction fraction OEF, and cerebrovascular reactivity CVR. CVR is measured by having participants inhale controlled amounts of carbon dioxide using an MRI-compatible device that ensures safe and steady delivery. The study includes healthy controls, survivors of extracorporeal membrane oxygenation ECMO, and individuals with sickle cell anemia. During the study, participants may have blood drawn, complete neuropsychological assessments, and be monitored for how their brain vessels respond to carbon dioxide inhalation. The main outcome measured is cerebral oxygen metabolism during the MRI scan, which takes about 75 minutes. Secondary outcomes include cerebrovascular reactivity measured over 15 minutes during carbon dioxide administration. The study runs through December 2027 and includes safety measures to prevent over-breathing carbon dioxide.

Cerebral Oxygen Metabolism in Children