Actively Recruiting
Led by National Institutes of Health Clinical Center (CC) · Updated on 2026-04-29
320
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying how the brain controls body movement in people with cerebral palsy compared to healthy individuals. This research uses non-invasive techniques like near-infrared spectroscopy (NIRS) and electroencephalography (EEG) to measure brain activity during movement. The study aims to better understand brain activation patterns in children and adults with childhood-onset brain or peripheral injuries and to explore new motor training approaches. The study has three parts: people with cerebral palsy participate in all parts, while healthy volunteers take part in two. All participants undergo NIRS and/or EEG imaging during movement tasks. Additional assessments may include magnetic resonance imaging (MRI), electromyography (EMG), motion analysis, ultrasound, and muscle stimulation. Participants with cerebral palsy may also receive biofeedback training sessions to improve coordination between brain activity and muscle movement. Participants will have a physical exam and medical history review, possibly including urine tests. Researchers will monitor brain and muscle activity across various tasks and groups, using these measures to compare cortical activation. The study will assess changes in brain activation and motor skills before and after training. Participants' involvement includes multiple imaging sessions and clinical tests, lasting as needed to complete the study objectives.
CONDITIONS
Cerebral Palsy and the Study of Brain Activity During Motor Tasks
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You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo neural imaging assessments using near-infrared spectroscopy (NIRS) and electroencephalography (EEG) during motor and sensory tasks to compare brain activation patterns.
1 visit (in-person)
Duration - Short-term, exact duration not specified
Participants with childhood-onset brain injury participate in a short-term motor training program using NIRS and/or EEG neurofeedback to improve brain activation and motor performance.
Multiple visits for training sessions
Duration - Duration not specified
Participants are observed for changes in brain activation and motor performance following the training program.
Follow-up visits depending on the training schedule
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
F
Functional & Applied Biomechanics Sectio
T
Thomas C Bulea, Ph.D.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Theresa Sukal-Moulton, Ana Carolina de Campos, Christopher J Stanley...
https://pubmed.ncbi.nlm.nih.gov/25548919