Study of High-Level Cognitive Impairments in Adults With Various Neuropsychiatric and Neurological Disorders Compared to Healthy Volunteers

What this Trial Is About

Researchers are investigating high-level cognitive impairments that occur across a broad range of severe neuropsychiatric and neurological disorders, including schizophrenia, mood disorders, autism spectrum disorders, obsessive-compulsive disorder, neurodegenerative diseases, focal neurological lesions, and epilepsy. This study aims to create a comprehensive atlas that identifies both shared and disorder-specific cognitive deficits by comparing patients cognitive performance to that of healthy volunteers. The study also plans to track changes in cognitive function over time and in relation to treatment or symptom changes, while exploring underlying brain mechanisms linked to these impairments. Participants will undergo computerized neuropsychological assessments covering various cognitive domains such as motivation, metacognition, conscious awareness, and causal inference. These tests will be adapted progressively to become shorter, more user-friendly, and digital-device compatible, based on participant feedback and interim results. Additional optional assessments include brain imaging techniques such as MRI without contrast, electroencephalography EEG, and magnetoencephalography MEG to explore neural correlates of cognitive deficits. The study is prospective and multicenter, involving both patients and healthy volunteers. During the study, participants will complete repeated cognitive tests at baseline and follow-up visits up to one year later to measure changes and optimize testing. Imaging assessments may occur between baseline and study completion and can extend up to 10 years for patients under clinical follow-up. Researchers will monitor cognitive performance scores and relate them to clinical changes and therapeutic interventions. The primary outcome is performance on validated computerized cognitive tasks, while secondary outcomes include imaging results and predictive capacity for differential diagnosis. This minimal-risk study supports creating a detailed database of cognitive dysfunctions across neuropsychiatric disorders.

Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders