Study of Chronic Endometritis and Antibiotic Treatment in Women Aged 20-45 With Recurrent Miscarriage

What this Trial Is About

This research aims to determine how often chronic endometritis CE occurs in women with unexplained recurrent miscarriage and to study the types of microorganisms involved in CE. It also investigates whether antibiotic treatments can help women who have CE and a history of multiple miscarriages. The study is observational and focuses on women aged 20 to 45 years with two or more consecutive miscarriages before 24 weeks of pregnancy. Women who join the study will undergo endometrial sampling during the mid-luteal phase, timed precisely seven days after their luteinizing hormone LH surge, detected by daily urine tests. The sample is collected using a Pipelle sampler during an outpatient visit. The tissue is analyzed for plasma cells, stromal cell changes, and infectious agents through microscopic and microbial tests. If CE is diagnosed, antibiotics are prescribed based on the infection type or given empirically, with treatment repeated up to three times if necessary. Participants will have repeat endometrial biopsies after antibiotic treatment to check for CE persistence. Researchers will monitor the incidence of CE, identify the microorganisms present, and compare pregnancy outcomes between women cured of CE and those without CE. The study involves outpatient procedures, laboratory tests, and clinical follow-ups, continuing until January 2027 to assess the therapeutic effects and pregnancy outcomes.

Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage