Actively Recruiting
Immune Cell Populations in the Endometrium
Led by Jagiellonian University · Updated on 2026-03-19
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood. In ovulatory cycles, changes occur in the populations of uterine lymphocytes, which may influence the receptivity of the endometrium and the implantation of the embryo. Particularly notable are the changes in natural killer (NK) cells, which reach their peak during the luteal phase and regulate the invasion of the trophoblast. The dominant NK cells exhibit a CD56bright phenotype and differ in cytokine profiles from peripheral blood cells. Cyclical changes also affect macrophages and T lymphocytes; however, it is unclear whether their proportions differ in women with reduced fertility. There is a need to investigate how the composition of lymphocytes in blood influences the populations in the endometrium. The aim of this study is to analyze the correlation between peripheral and endometrial lymphocytes in women with idiopathic infertility and recurrent miscarriages, compared to fertile women.
CONDITIONS
Official Title
Immune Cell Populations in the Endometrium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 45 years
- Idiopathic infertility
- At least 2 miscarriages
- Other benign gynecological conditions requiring endometrial sampling
You will not qualify if you...
- Miscarriage within the last 3 months
- Abdominal or uterine surgery within the last 3 months
- Viral or bacterial infection within the last 3 months
- Antibiotic therapy within the last 3 months
AI-Screening
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Trial Site Locations
Total: 1 location
1
Jagiellonian Univeristy
Krakow, Poland
Actively Recruiting
Research Team
I
Iwona Gawron, PhD, MD
CONTACT
R
Robert Jach, Prof., PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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