Actively Recruiting
Analysis of Immune Cell Populations in the Endometrium and Peripheral Blood in Women With Reduced and Normal Fertility
Led by Jagiellonian University · Updated on 2026-03-19
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the role of immune cells in women with idiopathic infertility and recurrent miscarriages, conditions where the immune system's involvement is not fully understood. The study focuses on changes in uterine lymphocytes, especially natural killer (NK) cells, macrophages, and T lymphocytes, which may affect the uterus's ability to allow embryo implantation. It compares immune cell populations in women with reduced fertility to those in women with normal fertility. The study collects a small endometrial biopsy and a peripheral blood sample from women aged 18 to 45 undergoing diagnostic procedures. These samples are analyzed using flow cytometry to measure various immune cell types, including monocytes, plasmocytes, lymphocytes, and NK cells, with specific markers to identify different subpopulations. The research examines how blood immune cell profiles correlate with those in the endometrium. Participants provide medical and reproductive histories, and their samples are tested for immune cell distribution. The study measures the percentages of various immune cells in blood and endometrial tissue over up to six months. Statistical methods will be used to analyze the relationships between immune cells in both sample types. This observational study helps deepen understanding of immune involvement in fertility and miscarriage.
CONDITIONS
Brief Title
Immune Cell Populations in the Endometrium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
- Diagnosed with idiopathic infertility
- History of at least two miscarriages
- Presence of other benign gynecological conditions requiring endometrial sampling
You will not qualify if you...
- Miscarriage within the last 3 months
- Abdominal or uterine surgery within the last 3 months
- Viral or bacterial infection within the last 3 months
- Antibiotic therapy within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment
Duration - 1 day
Participants undergo an endometrial biopsy and peripheral blood collection for analysis of immune cell populations.
1 visit (in-person) for biopsy and blood sample collection
Duration - Up to 6 months
Participants' immune cell populations are assessed and analyzed up to 6 months after sample collection.
No additional visits; monitoring is based on sample analysis
Trial Site Locations
Total: 1 location
1
Jagiellonian Univeristy
Krakow, Poland
Actively Recruiting
Research Team
I
Iwona Gawron, PhD, MD
R
Robert Jach, Prof., PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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