Is Plasma Level of Mannose Binding Lectin Associated With Reproductive Failure?

What this Trial Is About

Researchers are investigating the relationship between low plasma mannose binding lectin (p-MBL) levels and unexplained reproductive failures, including recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF). The study focuses on patients with reproductive difficulties after assisted reproductive technologies (ART) such as IVF, ICSI, and frozen embryo transfer (FET), as well as after spontaneous conception. The goal is to better understand if low p-MBL levels contribute broadly to reproductive challenges in early pregnancy stages. The study observes three groups of women: those with three consecutive pregnancy losses after spontaneous conception, three losses after ART treatments, and those who experienced three failed embryo transfers with good-quality embryos but no clinical pregnancy. Blood samples are collected from participants when they are not pregnant or before 9 weeks gestation to measure p-MBL levels, categorizing them as low, very low, or high. Participants undergo assessments including blood sampling to measure p-MBL levels, which are the primary outcomes of interest. Secondary measures include calculating the odds ratios for low p-MBL levels among these groups. The study excludes women outside the age range or with certain uterine or chromosomal conditions. The research aims to clarify p-MBL's role in early pregnancy failure mechanisms, helping future evaluation of reproductive failure cases.

Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction