Actively Recruiting
Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
Led by Massachusetts General Hospital · Updated on 2025-06-12
80
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive episode (MDE) or borderline personality disorder (BPD).
CONDITIONS
Official Title
Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 65 years of age
- Diagnosed with borderline personality disorder or major depressive episode
- Chief complaint of suicidal thoughts and behaviors
You will not qualify if you...
- Neurological conditions with known structural brain lesion
- Prior neurosurgical procedure
- Presence of ferromagnetic metal in the body or metal injury to the eyes
- Epilepsy
- Implanted devices such as pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, or ventriculo-peritoneal shunt
- Psychopathology not suitable for treatment (e.g., manic episode or psychosis)
- Current alcohol dependence or active withdrawal symptoms from non-alcohol psychoactive substances
- Inability to meet MRI safety criteria at MGH Department of Radiology
- Current pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129
Actively Recruiting
Research Team
D
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CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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