Actively Recruiting
Acute Effects of Physical Exercise in Patients with Borderline Personality Disorder
Led by University Hospital, Bonn · Updated on 2024-12-11
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how a single session of physical exercise affects stress regulation, cognitive and emotional function, and related biological processes in people with borderline personality disorder (BPD). This study also aims to find out which exercise intensity, moderate or high, is most beneficial. BPD involves emotional and behavioral challenges, and current treatments do not fully resolve symptoms, so exploring exercise effects is important. Participants will take part in two separate 30-minute sessions: one involving cycling on a stationary bike at either moderate or high intensity, and another where they watch a health-related documentary. Heart rate will be continuously monitored. The study includes 60 patients with BPD and 60 healthy controls, with exercise intensity tailored to each person's maximum heart rate. The sessions are spaced at least 48 hours apart and the order is randomized. Throughout the study, participants will complete tests before and after each session to measure impulsivity and emotion regulation. They will also undergo a stress test 90 minutes after each session. Researchers will collect saliva and blood samples and use questionnaires to assess stress levels, cognitive changes, emotional responses, and specific biomarkers linked to stress and BPD. The study monitors changes immediately and up to 30 minutes after the stress test, with the total participation spanning the two experimental days.
CONDITIONS
Brief Title
Acute Effects of Physical Exercise in Patients with Borderline Personality Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Estimated verbal intelligence quotient above 80
- Diagnosis of borderline personality disorder according to DSM-5
You will not qualify if you...
- Neurological disorders
- Health conditions interfering with exercise safety, such as coronary heart disease
- Visual impairments that may affect cognitive task performance
- Endocrine disorders, including hyperthyreosis or diabetes mellitus
- Psychiatric disorders including psychosis, affective disorders with psychotic symptoms, schizophrenia, substance abuse or dependence, autism spectrum disorders, anorexia nervosa
- For healthy controls: diagnosis of borderline personality disorder or use of psychotropic drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 separate days with at least 48 hours apart
Participants complete two 30-minute sessions on separate days: one involving physical exercise on a stationary ergometer at moderate or high intensity, and one watching a movie as a control condition. Each session involves cognitive and emotional tests before and after the activity, as well as a stress test with saliva and blood sample collection.
2 visits (each 1 session of exercise or control condition with assessments before and after)
Trial Site Locations
Total: 1 location
1
University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
Research Team
A
Aylin Mehren, Dr.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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