Study of One-Time Moderate or High-Intensity Cycling Effects on Stress and Brain Function in Adults with Borderline Personality Disorder

What this Trial Is About

Researchers are investigating how a single session of physical exercise affects stress regulation, cognitive and emotional function, and related biological processes in people with borderline personality disorder BPD. This study also aims to find out which exercise intensity, moderate or high, is most beneficial. BPD involves emotional and behavioral challenges, and current treatments do not fully resolve symptoms, so exploring exercise effects is important. Participants will take part in two separate 30-minute sessions one involving cycling on a stationary bike at either moderate or high intensity, and another where they watch a health-related documentary. Heart rate will be continuously monitored. The study includes 60 patients with BPD and 60 healthy controls, with exercise intensity tailored to each persons maximum heart rate. The sessions are spaced at least 48 hours apart and the order is randomized. Throughout the study, participants will complete tests before and after each session to measure impulsivity and emotion regulation. They will also undergo a stress test 90 minutes after each session. Researchers will collect saliva and blood samples and use questionnaires to assess stress levels, cognitive changes, emotional responses, and specific biomarkers linked to stress and BPD. The study monitors changes immediately and up to 30 minutes after the stress test, with the total participation spanning the two experimental days.

Acute Effects of Physical Exercise in Patients with Borderline Personality Disorder