Study of Insulin Secretion and Sensitivity in Adults with Liver Cirrhosis Before and After Liver Transplantation

What this Trial Is About

This research focuses on people with liver cirrhosis who are awaiting or have undergone orthotopic liver transplantation OLT. The study aims to evaluate insulin secretion and sensitivity by using mathematical models derived from oral glucose tolerance tests taken before and at several points after the transplantation. It also explores how changes in insulin function relate to the development or persistence of glucose metabolism issues over a 10-year follow-up. Additionally, it examines links between insulin changes and health outcomes like morbidity, mortality, and metabolic syndrome components such as obesity, dyslipidemia, and hypertension. Participants are monitored through routine clinical and laboratory tests, including glucose, insulin, and C-peptide levels measured at multiple time intervals during an oral glucose tolerance test. These tests are routinely performed before and after OLT. Data on cardiovascular risk factors, events, renal function, treatments, and other illnesses are also collected. The study follows patients for at least 10 years with yearly visits and death record consultations if participants drop out. Throughout the study, researchers track insulin secretion and sensitivity changes to understand their relationship with glucose metabolism abnormalities after transplantation. They also observe long-term health outcomes related to cardiovascular and metabolic conditions. This observational study was approved by the Ethics Committee and began data transfer in 2013, continuing with ongoing patient follow-up visits for comprehensive monitoring.

Cirrhosis, Effects of TRAnsplantation and Diabetes