Actively Recruiting
Coagulation in Cirrhosis
Led by Medical University of Vienna · Updated on 2025-01-14
400
Participants Needed
1
Research Sites
214 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out of fear of bleeding, liver cirrhosis patients are often treated prophylactically with blood and coagulation products before minor interventions. The COUCH study will examine whether these patients benefit from a restrictive administration of coagulation products.
CONDITIONS
Official Title
Coagulation in Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients at the University Hospital of Vienna with diagnosed liver cirrhosis and abnormal coagulation parameters (INR >1.5 and/or platelet count <50 G/L)
- Scheduled for elective invasive liver interventions including biopsy or puncture, microwave ablation (MWA) or radiofrequency ablation (RFA), transjugular intrahepatic portosystemic shunt (TIPS), or percutaneous transhepatic cholangiography drain (PTCD)
- Adults aged 18 years or older
You will not qualify if you...
- Missing informed consent or inability to consent
- Age younger than 18 years
- Pregnancy or breastfeeding
- Presence of manifest ascites
- Chronic kidney injury stage G4 or G5 according to KDIGO
- Uninterrupted anticoagulant therapy, except acetylsalicylic acid (ASA)
- History of bleeding or clinical signs of hemorrhagic diathesis such as petechia, ecchymosis, mucosal bleeding, family history of bleeding disorders, menorrhagia, or prolonged bleeding after surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
General Hospital of the Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
Research Team
A
Armin Langauer, MD
CONTACT
K
Kristina Nieding, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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