Non-Invasive Breast Tissue Diagnosis Using Optical Imaging Techniques Diffuse Reflectance Spectroscopy and Photoacoustic Imaging

What this Trial Is About

Breast cancer is a common cancer among women globally, and current diagnostic methods have limitations such as exposure to radiation and the need for invasive biopsies. Researchers are evaluating two optical imaging techniques, diffuse reflectance spectroscopy DRS and photoacoustic imaging PAI, to differentiate healthy, benign, and malignant breast tissues by identifying their unique optical profiles. This study aims to assess these methods as non-invasive, contrast-free alternatives to traditional imaging for breast cancer diagnosis or monitoring. The study has three parts first, 30 breast tissue samples will be examined outside the body using DRS second, 30 samples will be examined ex-vivo using both DRS and PAI third, 30 participants will undergo in-vivo examination using PAI. The DRS device uses white light to generate optical signals, while PAI combines ultrasound with optical imaging to create functional images that may assess tissue oxygenation differences. Participants will be evaluated through these imaging techniques to classify tissue types accurately. Outcomes include the number of subjects with correctly classified breast tissue using PAI and DRS, optical signal depth, and oxygenation levels in different tissue types. The study uses non-invasive imaging without ionizing radiation or contrast agents, with evaluations completed within days after imaging. Total participation time varies by study part.

Clinical Explorative Optical Breast Investigations