Actively Recruiting
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
Led by University of Leeds · Updated on 2025-03-30
4500
Participants Needed
76
Research Sites
1190 weeks
Total Duration
On this page
Sponsors
U
University of Leeds
Lead Sponsor
U
University of Oxford
Collaborating Sponsor
AI-Summary
What this Trial Is About
A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.
CONDITIONS
Official Title
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean.
- Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms.
- Able and willing to give informed consent.
- Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA.
You will not qualify if you...
- Patient unwilling or unable to give fully informed consent.
AI-Screening
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Trial Site Locations
Total: 76 locations
1
Queen Elizabeth The Queen Mother Hospital
Canterbury, Kent, United Kingdom, CT 1 3NG
Actively Recruiting
2
Whiston Hospital
Prescot, Merseyside, United Kingdom, L35 5DR
Actively Recruiting
3
Nevill Hall Hospital, Aneurin Bevan University Health Board
Abergavenny, United Kingdom
Actively Recruiting
4
Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
Actively Recruiting
5
Betsi Cadwaladr University Health Board
Bangor, United Kingdom, LL57 2PW
Actively Recruiting
6
Barnsley Hospital, Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
Completed
7
Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust
Basildon, United Kingdom
Actively Recruiting
8
Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
Actively Recruiting
9
Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
Actively Recruiting
10
Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Actively Recruiting
11
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Actively Recruiting
12
Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Actively Recruiting
13
Queen's Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
Burton-on-Trent, United Kingdom
Actively Recruiting
14
West Suffolk Hospital, West Suffolk NHS Foundation Trust
Bury St Edmunds, United Kingdom
Actively Recruiting
15
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Actively Recruiting
16
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
Actively Recruiting
17
West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
Actively Recruiting
18
Ashford and St Peter's Hospitals, Ashford & St Peter's Hospitals NHS Foundation Trust
Chertsey, United Kingdom
Actively Recruiting
19
Countess of Chester Hospital, Countess of Chester NHS Foundation Trust
Chester, United Kingdom
Actively Recruiting
20
Christchurch Hospital, University Hospitals Dorset NHS Foundation Trust
Christchurch, United Kingdom
Actively Recruiting
21
Croydon University Hospital, Croydon Health Service NHS Trust
Croydon, United Kingdom
Actively Recruiting
22
Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust
Darlington, United Kingdom
Actively Recruiting
23
Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
Derby, United Kingdom
Actively Recruiting
24
Doncaster Royal Infirmary, Doncaster and Bassetlaw Hospitals NHS Foundation Trust
Doncaster, United Kingdom
Actively Recruiting
25
Ninewells Hospital and Medical School, NHS Tayside
Dundee, United Kingdom
Completed
26
Royal Devon and Exeter Hospital, Royal Devon and Exeter NHS Foundation Trust
Exeter, United Kingdom
Actively Recruiting
27
Frimley Park Hospital, Frimley Park Hospital NHS Foundation Trust
Frimley, United Kingdom
Completed
28
Gateshead Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust
Gateshead, United Kingdom
Actively Recruiting
29
Inverclyde Royal Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Completed
30
Royal Alexandra Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Completed
31
Vale of Leven Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Completed
32
James Paget Hospital, James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, United Kingdom
Completed
33
Royal Surrey County Hospital, Royal Surrey County Hospital NHS Foundation Trust
Guildford, United Kingdom
Completed
34
Harrogate and District Hospital, Harrogate and District NHS Foundation Trust
Harrogate, United Kingdom
Actively Recruiting
35
Hull Royal Infirmary, Hull and East Yorkshire NHS Trust
Hull, United Kingdom
Actively Recruiting
36
Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust
Ipswich, United Kingdom
Completed
37
Airedale General Hospital, Airedale NHS Foundation Trust
Keighley, United Kingdom
Actively Recruiting
38
Westmorland General Hospital, University Hospitals of Morecambe Bay NHS Foundation Trust
Kendal, United Kingdom
Actively Recruiting
39
The Queen Elizabeth Hospital, The Queen Elizabeth Hospital Kings Lynn NHS Foundation Trust
Kings Lynn, United Kingdom
Completed
40
Royal Lancaster Infirmary, University Hospitals of Morecambe NHS Foundation Trust
Lancaster, United Kingdom
Actively Recruiting
41
Chapel Allerton Hospital, Leeds Teaching Hospitals NHS Foundation Trust
Leeds, United Kingdom
Actively Recruiting
42
Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
Actively Recruiting
43
Aintree University Hospital, Aintree University Hospitals NHS Trust
Liverpool, United Kingdom
Actively Recruiting
44
Royal Glamorgan Hospital, Cwm Taf University Health Board
Llantrisant, United Kingdom
Actively Recruiting
45
Hammersmith Hospital, Imperial College Healthcare NHS Trust
London, United Kingdom
Actively Recruiting
46
King's College Hospital, King's College Hospital NHS Foundation Trust, London
London, United Kingdom
Actively Recruiting
47
Royal Free Hospital, Royal Free NHS Foundation Trust
London, United Kingdom
Actively Recruiting
48
St George's Hospital, St George's University Hospitals NHS Foundation Trust
London, United Kingdom
Actively Recruiting
49
University College London Hospital, University College London NHS Foundation Trust
London, United Kingdom
Actively Recruiting
50
Manchester Royal Infirmary, Manchester University NHS Foundation Trust
Manchester, United Kingdom
Actively Recruiting
51
Arrowe Park Hospital, Wirral University Hospital NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom
Actively Recruiting
52
Freeman Hospital, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
Actively Recruiting
53
North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust
North Shields, United Kingdom
Actively Recruiting
54
Northampton General Hospital, Northampton General Hospital NHS Trust
Northampton, United Kingdom
Actively Recruiting
55
Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom
Completed
56
Queens Medical Centre, Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Actively Recruiting
57
Oxford Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust
Oxford, United Kingdom
Not Yet Recruiting
58
Peterborough City Hospital, North West Anglia NHS Foundation Trust
Peterborough, United Kingdom
Actively Recruiting
59
Derriford Hospital, University Hospital Plymouth NHS Trust
Plymouth, United Kingdom
Actively Recruiting
60
Poole Hospital, University Hospitals Dorset NHS Foundation Trust
Poole, United Kingdom
Actively Recruiting
61
Minerva Health Centre, Lancashire and South Cumbria NHS Foundation Trust
Preston, United Kingdom
Actively Recruiting
62
Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom
Actively Recruiting
63
Salford Royal Hospital, Salford Royal NHS Foundation Trust
Salford, United Kingdom
Actively Recruiting
64
Scarborough General Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
Scarborough, United Kingdom
Actively Recruiting
65
Southend University Hospital, Southend University Hospital NHS Foundation Trust
Southend-on-Sea, United Kingdom
Actively Recruiting
66
Lister Hospital, East and North Hertfordshire NHS Trust
Stevenage, United Kingdom
Actively Recruiting
67
Haywood Hospital, Midlands Partnership NHS Foundation Trust
Stoke-on-Trent, United Kingdom
Actively Recruiting
68
Great Western Hospital, The Great Western Hospitals NHS Foundation Trust
Swindon, United Kingdom
Actively Recruiting
69
Torbay Hospital, Torbay and South Devon NHS Foundation Trust
Torquay, United Kingdom
Completed
70
Royal Cornwall Hospital, Royal Cornwall Hospitals NHS Trust
Truro, United Kingdom
Actively Recruiting
71
Pinderfields Hospital, Mid Yorkshire Hospitals NHS Trust
Wakefield, United Kingdom
Actively Recruiting
72
Warrington Hospital, Warrington and Halton Hospitals NHS Foundation Trust
Warrington, United Kingdom
Actively Recruiting
73
Warwick Hospital, South Warwickshire NHS Foundation Trust
Warwick, United Kingdom
Completed
74
Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust
Winchester, United Kingdom
Actively Recruiting
75
University Hospital Wishaw, NHS Lanarkshire
Wishaw, United Kingdom
Actively Recruiting
76
York Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
York, United Kingdom
Completed
Research Team
L
Louise Sorensen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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