Actively Recruiting
Clinical Phenotyping Resource and Biobank Core of the Michigan O'Brien Renal Center
Led by University of Michigan · Updated on 2024-10-04
1800
Participants Needed
5
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
S
St. John Health System, Michigan
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic kidney disease (CKD) affects millions of people in the United States, with higher impact in certain racial and ethnic groups. This condition leads to serious health problems and shorter life expectancy, creating a significant public health challenge and high economic costs. The Michigan O'Brien Renal Center aims to advance research by creating a resource that characterizes kidney disease patients through clinical and biological data to better understand disease markers and pathways. The study involves collecting detailed clinical information and biological samples such as blood, urine, and kidney tissue from patients with CKD, healthy controls, and family members of pediatric CKD patients. This resource supports research by providing access to well-characterized patient data and specimens, especially from high-risk and minority populations. Samples and data are collected from multiple healthcare institutions, contributing to the center's biobank and research core. Participants will be observed and their clinical features documented without receiving specific treatments as part of the study. Researchers will use the collected data and biological specimens to conduct translational research aimed at improving understanding of CKD progression. The study includes people with and without CKD and involves follow-up assessments to support ongoing kidney disease research, with participation lasting as long as needed for data collection and sample contribution.
CONDITIONS
Brief Title
Clinical Phenotyping Resource and Biobank Core of the Michigan O'Brien Renal Center
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persons of any age who have chronic kidney disease, indicated by abnormally high protein in urine or reduced kidney function determined by blood tests
- A small number of people without chronic kidney disease
You will not qualify if you...
- People on hemodialysis or peritoneal dialysis
- People who have had a kidney transplant
- People unable or unwilling to provide consent
- Women who are pregnant or nursing
- Adults who have polycystic kidney disease
- Institutionalized persons
- People currently participating in a blinded interventional clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Ongoing throughout study participation
Participants undergo clinical phenotyping and sample collection to assess kidney function and related health parameters.
Initial and periodic visits depending on cohort assignment
Duration - Up to July 2030
Participants are monitored over time to observe the progression of kidney disease or health status in controls and relatives.
Periodic visits scheduled as per study protocol
Trial Site Locations
Total: 5 locations
1
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
2
Wayne State University
Detroit, Michigan, United States, 48201
Completed
3
St. John's Health System
Detroit, Michigan, United States, 48236
Completed
4
Levine Children's Hospital
Charlotte, North Carolina, United States, 28207
Completed
5
Temple University
Philadelphia, Pennsylvania, United States, 19140
Completed
Research Team
C
Chrysta Lienczewski
M
Markus Bitzer, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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