Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05257135

Development of a Prospective Clinico-biological Database in Cachexia in Patients With Colon Cancer

Led by Institut du Cancer de Montpellier - Val d'Aurelle · Updated on 2025-02-13

150

Participants Needed

1

Research Sites

156 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are developing a prospective clinico-biological database focused on cachexia and undernutrition in patients with colon cancer. Cachexia is a serious syndrome marked by rapid, involuntary weight loss affecting fat and muscle tissues, which can contribute to treatment failure and increased mortality. This study aims to improve understanding of cachexia to enhance patient care and survival by integrating nutritional approaches and clinical nutrition advancements. Participants will have blood samples collected at the start of the study and every six months during treatment, alongside standardized clinical data entered into a database. This collection supports future research projects aimed at tailoring management strategies for patients with colon cancer-related cachexia. The study involves patients treated at a regional cancer institute and monitors biological and clinical risk factors over six years. During the study, participants will undergo regular clinical assessments and blood sample collections to track nutritional and metabolic changes. Researchers will measure the number of clinical and biological risk factors for colorectal cancer until the study's completion. This ongoing monitoring will help identify factors influencing treatment response and toxicity. Participation continues for up to six years, allowing long-term data collection and follow-up.

CONDITIONS

Brief Title

A Clinico-biological Database in Cachexia in Patients With Colon Cancer

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Treated at the Montpellier Regional Cancer Institute for colon cancer not eligible for surgery
  • Undergoing or requiring treatment for colon cancer such as chemotherapy or targeted therapy
  • Accepted the research requirements including blood sample collection
  • Affiliated with the Social Protection system
  • Signed informed consent form
Not Eligible

You will not qualify if you...

  • Requiring surgery for colon cancer or metastasis
  • Having exclusive peritoneal carcinomatosis
  • Requiring radiotherapy
  • Unable to understand or comply with study instructions due to psychological, family, social, or geographical reasons
  • Pregnant or breastfeeding women
  • Receiving care in an emergency context

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Biological Collection

Duration - Up to 6 years

Participants provide blood samples at inclusion and during treatment every 6 months, while clinical data is also collected into a database.

Blood samples collected every 6 months

Trial Site Locations

Total: 1 location

1

Institut Régional du cancer de Montpellier

Montpellier, France, 34298

Actively Recruiting

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Research Team

J

Jean-Pierre Bleuse, MD

A

Aurore Moussion

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

OTHER

Number of Arms

1

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Published Research Related To This Trial

French clinical guidelines on perioperative nutrition. Update of the 1994 consensus conference on perioperative artificial nutrition for elective surgery in adults.

C Chambrier, F Sztark, Société Francophone de nutrition clinique et métabolisme (SFNEP)...

https://pubmed.ncbi.nlm.nih.gov/23107793

Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index.

Lisa Martin, Laura Birdsell, Neil Macdonald...

https://pubmed.ncbi.nlm.nih.gov/23530101

Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma.

S Antoun, V E Baracos, L Birdsell...

https://pubmed.ncbi.nlm.nih.gov/20089558

Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis.

Vickie E Baracos, Tony Reiman, Marina Mourtzakis...

https://pubmed.ncbi.nlm.nih.gov/20164322