Actively Recruiting
COAgulation Disorders in Ischaemic and Haemorrhagic Stroke
Led by Ziekenhuis Oost-Limburg · Updated on 2024-11-14
350
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
Z
Ziekenhuis Oost-Limburg
Lead Sponsor
S
Synapse bv
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.
CONDITIONS
Official Title
COAgulation Disorders in Ischaemic and Haemorrhagic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presenting at the hospital with ischemic stroke, hemorrhagic stroke, aneurysmal subarachnoid hemorrhage, or any other type of non-traumatic intracranial bleeding
- For patients with minor ischemic stroke (NIH Stroke Scale score of 4 or less), only baseline blood samples will be taken (at admission and next morning)
- Age 18 years or older
You will not qualify if you...
- Refusal to participate by the patient or their legal representative
- Traumatic intracranial bleeding such as subdural, subarachnoid, or epidural hematoma
- Receiving treatments that affect blood clotting before the first blood sample; these patients will not have coagulation assessed at presentation but may continue with further lab testing
- Patients diagnosed with conditions that mimic stroke will be excluded from analysis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ziekenhuis Oost-Limburg
Genk, Belgium, 3600
Actively Recruiting
Research Team
H
Hendrik Stragier, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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